Synthesis and scale-up of water-soluble quaternary cationic monomers in a continuous flow system

Zheng Fang; Yuhang Yang; Jiajia Gu; Zhao Yang; Feiyang Dai; Haoliang Zheng; Wei He; Chengkou Liu; Ning Zhu; Kai Guo

doi:10.1039/c8re00335a

Synthesis and scale-up of water-soluble quaternary cationic monomers in a continuous flow system

Zheng Fang, Yuhang Yang, Jiajia Gu, Zhao Yang, Feiyang Dai, Haoliang Zheng, Wei He, Chengkou Liu, Ning Zhu, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A continuous flow technology was developed for the synthesis and scale-up of water-soluble quaternary cationic monomers represented by dimethyldiallylammonium chloride (DMDAAC) in a self-designed reactor. For industrial applications, static mixers were employed in a self-designed scaled-up reactor to maintain the mass and heat transfer rates from microfluidics to mesofluidics during the scale-up. Three different types of static mixers were investigated, and their optimal combination was determined. Various factors including the reaction temperature, fluid rate, and reagent concentration were also investigated in detail. This work increased the yield up to 92% under optimal conditions with an output of one kiloton per year. Moreover, this proposed method exhibited excellent performance in the synthesis and scale-up of other water-soluble quaternary cationic monomers in a continuous flow system.

Original language	English
Pages (from-to)	919-926
Number of pages	8
Journal	Reaction Chemistry and Engineering
Volume	4
Issue number	5
DOIs	https://doi.org/10.1039/c8re00335a
State	Published - May 2019

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abstract = "A continuous flow technology was developed for the synthesis and scale-up of water-soluble quaternary cationic monomers represented by dimethyldiallylammonium chloride (DMDAAC) in a self-designed reactor. For industrial applications, static mixers were employed in a self-designed scaled-up reactor to maintain the mass and heat transfer rates from microfluidics to mesofluidics during the scale-up. Three different types of static mixers were investigated, and their optimal combination was determined. Various factors including the reaction temperature, fluid rate, and reagent concentration were also investigated in detail. This work increased the yield up to 92% under optimal conditions with an output of one kiloton per year. Moreover, this proposed method exhibited excellent performance in the synthesis and scale-up of other water-soluble quaternary cationic monomers in a continuous flow system.",

author = "Zheng Fang and Yuhang Yang and Jiajia Gu and Zhao Yang and Feiyang Dai and Haoliang Zheng and Wei He and Chengkou Liu and Ning Zhu and Kai Guo",

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AU - Fang, Zheng

AU - Yang, Yuhang

AU - Gu, Jiajia

AU - Yang, Zhao

AU - Dai, Feiyang

AU - Zheng, Haoliang

AU - He, Wei

AU - Liu, Chengkou

AU - Zhu, Ning

AU - Guo, Kai

PY - 2019/5

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N2 - A continuous flow technology was developed for the synthesis and scale-up of water-soluble quaternary cationic monomers represented by dimethyldiallylammonium chloride (DMDAAC) in a self-designed reactor. For industrial applications, static mixers were employed in a self-designed scaled-up reactor to maintain the mass and heat transfer rates from microfluidics to mesofluidics during the scale-up. Three different types of static mixers were investigated, and their optimal combination was determined. Various factors including the reaction temperature, fluid rate, and reagent concentration were also investigated in detail. This work increased the yield up to 92% under optimal conditions with an output of one kiloton per year. Moreover, this proposed method exhibited excellent performance in the synthesis and scale-up of other water-soluble quaternary cationic monomers in a continuous flow system.

AB - A continuous flow technology was developed for the synthesis and scale-up of water-soluble quaternary cationic monomers represented by dimethyldiallylammonium chloride (DMDAAC) in a self-designed reactor. For industrial applications, static mixers were employed in a self-designed scaled-up reactor to maintain the mass and heat transfer rates from microfluidics to mesofluidics during the scale-up. Three different types of static mixers were investigated, and their optimal combination was determined. Various factors including the reaction temperature, fluid rate, and reagent concentration were also investigated in detail. This work increased the yield up to 92% under optimal conditions with an output of one kiloton per year. Moreover, this proposed method exhibited excellent performance in the synthesis and scale-up of other water-soluble quaternary cationic monomers in a continuous flow system.

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Synthesis and scale-up of water-soluble quaternary cationic monomers in a continuous flow system

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