Synthesis of α-Hydroxyl and α-Amino Pyridinyl Esters via Photoreductive Dual Radical Cross-Coupling

Xian Chao Cui; Hu Zhang; Hao Zhang; Yi Ping Wang; Jian Ping Qu; Yan Biao Kang

doi:10.1021/acs.orglett.3c02780

Synthesis of α-Hydroxyl and α-Amino Pyridinyl Esters via Photoreductive Dual Radical Cross-Coupling

Xian Chao Cui, Hu Zhang, Hao Zhang, Yi Ping Wang, Jian Ping Qu, Yan Biao Kang

School of Chemistry and Moleculai Engineering

University of Science and Technology of China

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A method for the synthesis of α-hydroxyl and α-amino pyridinyl esters via photoreductive dual radical cross-coupling catalyzed by the super-organoreductant CBZ6 has been developed. A wide range of 2-pyridinylation and 4-pyridinylation of either α-ketoesters or imine derivatives has been achieved. The applications in the synthesis of pyridinyl amino-hydroxyl acids as well as a new chiral oxazoline ligand have also been accomplished.

Original language	English
Pages (from-to)	7198-7203
Number of pages	6
Journal	Organic Letters
Volume	25
Issue number	39
DOIs	https://doi.org/10.1021/acs.orglett.3c02780
State	Published - 6 Oct 2023

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title = "Synthesis of α-Hydroxyl and α-Amino Pyridinyl Esters via Photoreductive Dual Radical Cross-Coupling",

abstract = "A method for the synthesis of α-hydroxyl and α-amino pyridinyl esters via photoreductive dual radical cross-coupling catalyzed by the super-organoreductant CBZ6 has been developed. A wide range of 2-pyridinylation and 4-pyridinylation of either α-ketoesters or imine derivatives has been achieved. The applications in the synthesis of pyridinyl amino-hydroxyl acids as well as a new chiral oxazoline ligand have also been accomplished.",

author = "Cui, {Xian Chao} and Hu Zhang and Hao Zhang and Wang, {Yi Ping} and Qu, {Jian Ping} and Kang, {Yan Biao}",

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doi = "10.1021/acs.orglett.3c02780",

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T1 - Synthesis of α-Hydroxyl and α-Amino Pyridinyl Esters via Photoreductive Dual Radical Cross-Coupling

AU - Cui, Xian Chao

AU - Zhang, Hu

AU - Zhang, Hao

AU - Wang, Yi Ping

AU - Qu, Jian Ping

AU - Kang, Yan Biao

PY - 2023/10/6

Y1 - 2023/10/6

N2 - A method for the synthesis of α-hydroxyl and α-amino pyridinyl esters via photoreductive dual radical cross-coupling catalyzed by the super-organoreductant CBZ6 has been developed. A wide range of 2-pyridinylation and 4-pyridinylation of either α-ketoesters or imine derivatives has been achieved. The applications in the synthesis of pyridinyl amino-hydroxyl acids as well as a new chiral oxazoline ligand have also been accomplished.

AB - A method for the synthesis of α-hydroxyl and α-amino pyridinyl esters via photoreductive dual radical cross-coupling catalyzed by the super-organoreductant CBZ6 has been developed. A wide range of 2-pyridinylation and 4-pyridinylation of either α-ketoesters or imine derivatives has been achieved. The applications in the synthesis of pyridinyl amino-hydroxyl acids as well as a new chiral oxazoline ligand have also been accomplished.

UR - http://www.scopus.com/inward/record.url?scp=85175189592&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.3c02780

DO - 10.1021/acs.orglett.3c02780

M3 - 文章

AN - SCOPUS:85175189592

SN - 1523-7060

VL - 25

SP - 7198

EP - 7203

JO - Organic Letters

JF - Organic Letters

IS - 39

ER -

Synthesis of α-Hydroxyl and α-Amino Pyridinyl Esters via Photoreductive Dual Radical Cross-Coupling

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