Abstract
1-(2-Cyan)-phenyl-3-methyl-5-pyrazolone is synthesized from 2-aminobenzonitrile by diazotization, reduction with stannous chloride in the presence of hydrochloric acid to give 2-cyanphenylhydrazine hydrochloride, which is subjected to neutralization with sodium methoxide and nucleophilic reaction with methyl acetoacetate. The method has been improved in the process of synthesis of 2-cyanphenylhydrazine hydrochloride and 1-(2-cyan)-phenyl-3-methyl-5-pyrazolone and the total yield can be increased to 79.4%.
| Original language | English |
|---|---|
| Pages (from-to) | 56-57 |
| Number of pages | 2 |
| Journal | Xiandai Huagong/Modern Chemical Industry |
| Volume | 29 |
| Issue number | 8 |
| State | Published - Aug 2009 |
Keywords
- 1-(2-cyan)-phenyl-3-methyl-5-pyrazolone
- Nerve protection injection
- Synthesis