TY - JOUR
T1 - Synthesis of 2,4,6-Trisubstituted Pyrimidines through Copper-Catalyzed [4 + 2] Annulation of α,β-Unsaturated Ketoximes with Activated Nitriles
AU - Wang, Xuemei
AU - Yan, Huan
AU - Jia, Chenglong
AU - Fang, Zheng
AU - Duan, Jindian
AU - Guo, Kai
N1 - Publisher Copyright:
© 2023 American Chemical Society
PY - 2023/9/1
Y1 - 2023/9/1
N2 - The copper-catalyzed [4 + 2] annulation of α,β-unsaturated ketoximes with activated nitriles for the rapid construction of 2,4,6-trisubstituted pyrimidines in moderate to good yields has been developed. The reaction features synthetic simplicity, good functional group tolerance, and gram-scale applicability. A plausible mechanism is proposed based on mechanistic investigations.
AB - The copper-catalyzed [4 + 2] annulation of α,β-unsaturated ketoximes with activated nitriles for the rapid construction of 2,4,6-trisubstituted pyrimidines in moderate to good yields has been developed. The reaction features synthetic simplicity, good functional group tolerance, and gram-scale applicability. A plausible mechanism is proposed based on mechanistic investigations.
UR - http://www.scopus.com/inward/record.url?scp=85169924249&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.3c00687
DO - 10.1021/acs.joc.3c00687
M3 - 文章
AN - SCOPUS:85169924249
SN - 0022-3263
VL - 88
SP - 12236
EP - 12243
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 17
ER -