Synthesis of Benzofuro[3,2- c ]isoquinolines through Anionic Intramolecular Cyclization

Bo Yang; Peng Fei Dai; Jian Ping Qu; Yan Biao Kang

doi:10.1055/a-2591-8986

Synthesis of Benzofuro[3,2- c ]isoquinolines through Anionic Intramolecular Cyclization

Bo Yang, Peng Fei Dai, Jian Ping Qu, Yan Biao Kang

School of Chemistry and Moleculai Engineering

University of Science and Technology of China

Research output: Contribution to journal › Article › peer-review

Abstract

Benzofuro[3,2- c ]isoquinolines are among the typical tetraheterocycles. The synthesis of benzofuro[3,2- c ]isoquinoline derivatives in the presence of a catalytic amount of KOH has been developed. A variety of substituents could be tolerated. The base (KOH) works as a catalyst. A gram-scale synthesis was performed. Control experiments confirmed that a cascade anionic annulation is involved rather than a radical cyclization.

Original language	English
Journal	Synthesis (Germany)
DOIs	https://doi.org/10.1055/a-2591-8986
State	Accepted/In press - 2025

Keywords

base
benzofuro[3,2- c ]isoquinolines
cascade annulation
catalyst free
tetraheterocycles
transition-metal-free

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10.1055/a-2591-8986

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title = "Synthesis of Benzofuro[3,2- c ]isoquinolines through Anionic Intramolecular Cyclization",

abstract = "Benzofuro[3,2- c ]isoquinolines are among the typical tetraheterocycles. The synthesis of benzofuro[3,2- c ]isoquinoline derivatives in the presence of a catalytic amount of KOH has been developed. A variety of substituents could be tolerated. The base (KOH) works as a catalyst. A gram-scale synthesis was performed. Control experiments confirmed that a cascade anionic annulation is involved rather than a radical cyclization.",

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author = "Bo Yang and Dai, {Peng Fei} and Qu, {Jian Ping} and Kang, {Yan Biao}",

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doi = "10.1055/a-2591-8986",

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journal = "Synthesis (Germany)",

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T1 - Synthesis of Benzofuro[3,2- c ]isoquinolines through Anionic Intramolecular Cyclization

AU - Yang, Bo

AU - Dai, Peng Fei

AU - Qu, Jian Ping

AU - Kang, Yan Biao

PY - 2025

Y1 - 2025

N2 - Benzofuro[3,2- c ]isoquinolines are among the typical tetraheterocycles. The synthesis of benzofuro[3,2- c ]isoquinoline derivatives in the presence of a catalytic amount of KOH has been developed. A variety of substituents could be tolerated. The base (KOH) works as a catalyst. A gram-scale synthesis was performed. Control experiments confirmed that a cascade anionic annulation is involved rather than a radical cyclization.

AB - Benzofuro[3,2- c ]isoquinolines are among the typical tetraheterocycles. The synthesis of benzofuro[3,2- c ]isoquinoline derivatives in the presence of a catalytic amount of KOH has been developed. A variety of substituents could be tolerated. The base (KOH) works as a catalyst. A gram-scale synthesis was performed. Control experiments confirmed that a cascade anionic annulation is involved rather than a radical cyclization.

KW - base

KW - benzofuro[3,2- c ]isoquinolines

KW - cascade annulation

KW - catalyst free

KW - tetraheterocycles

KW - transition-metal-free

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DO - 10.1055/a-2591-8986

M3 - 文章

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SN - 0039-7881

JO - Synthesis (Germany)

JF - Synthesis (Germany)

ER -

Synthesis of Benzofuro[3,2- c ]isoquinolines through Anionic Intramolecular Cyclization

Abstract

Keywords

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