Abstract
N-benzyloxycarbonyl-L-asparagine underwent cyclization, esterification, methylation, De-Cbz reaction to afford the key intermediate (4S)-1-methyl-2-oxo-imidazolin-4-carboxylic acid tert-butyl, followed by acylation with N-[(S)-1-ethyoxyoxo-3-phenylpropyl]-L-alanine and removal of tertbutyl group using hydrochloride gas to generate imidapril hydrochloride. The total yield is about 26%(based on N-Carbobenzyloxy-L-asparagine).
| Original language | English |
|---|---|
| Pages (from-to) | 150-151+153 |
| Journal | Xiandai Huagong/Modern Chemical Industry |
| Volume | 31 |
| Issue number | SUPPL. 1 |
| State | Published - Jun 2011 |
Keywords
- Angiotensin-converting enzyme inhibitors
- Imidapril hydrochloride
- Synthesis