Synthesis of imidazo[1,2-a]pyridinones via a visible light-photocatalyzed functionalization of alkynes/nitrile insertion/cyclization tandem sequence using micro-flow technology

Minghui Wei; Jiankun Chen; Chengkou Liu; Zhao Yang; Hong Qin; Yujing Hu; Jindian Duan; Yuguang Li; Zheng Fang; Kai Guo

doi:10.1039/d3qo01508d

Synthesis of imidazo[1,2-a]pyridinones via a visible light-photocatalyzed functionalization of alkynes/nitrile insertion/cyclization tandem sequence using micro-flow technology

Minghui Wei, Jiankun Chen, Chengkou Liu, Zhao Yang, Hong Qin, Yujing Hu, Jindian Duan, Yuguang Li, Zheng Fang, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

Abstract

We successfully developed an unprecedented route for imidazo[1,2-a]pyridinone synthesis through a visible light-photocatalysed functionalization of alkynes/nitrile insertion/cyclization tandem sequence in a microchannel reactor. This novel protocol features extremely mild conditions, broad substrate scope and high reaction efficiency. In addition, a reasonable reaction mechanism was proposed based on control experiments.

Original language	English
Pages (from-to)	83-88
Number of pages	6
Journal	Organic Chemistry Frontiers
Volume	11
Issue number	1
DOIs	https://doi.org/10.1039/d3qo01508d
State	Published - 17 Nov 2023

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title = "Synthesis of imidazo[1,2-a]pyridinones via a visible light-photocatalyzed functionalization of alkynes/nitrile insertion/cyclization tandem sequence using micro-flow technology",

abstract = "We successfully developed an unprecedented route for imidazo[1,2-a]pyridinone synthesis through a visible light-photocatalysed functionalization of alkynes/nitrile insertion/cyclization tandem sequence in a microchannel reactor. This novel protocol features extremely mild conditions, broad substrate scope and high reaction efficiency. In addition, a reasonable reaction mechanism was proposed based on control experiments.",

author = "Minghui Wei and Jiankun Chen and Chengkou Liu and Zhao Yang and Hong Qin and Yujing Hu and Jindian Duan and Yuguang Li and Zheng Fang and Kai Guo",

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doi = "10.1039/d3qo01508d",

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T1 - Synthesis of imidazo[1,2-a]pyridinones via a visible light-photocatalyzed functionalization of alkynes/nitrile insertion/cyclization tandem sequence using micro-flow technology

AU - Wei, Minghui

AU - Chen, Jiankun

AU - Liu, Chengkou

AU - Yang, Zhao

AU - Qin, Hong

AU - Hu, Yujing

AU - Duan, Jindian

AU - Li, Yuguang

AU - Fang, Zheng

AU - Guo, Kai

PY - 2023/11/17

Y1 - 2023/11/17

N2 - We successfully developed an unprecedented route for imidazo[1,2-a]pyridinone synthesis through a visible light-photocatalysed functionalization of alkynes/nitrile insertion/cyclization tandem sequence in a microchannel reactor. This novel protocol features extremely mild conditions, broad substrate scope and high reaction efficiency. In addition, a reasonable reaction mechanism was proposed based on control experiments.

AB - We successfully developed an unprecedented route for imidazo[1,2-a]pyridinone synthesis through a visible light-photocatalysed functionalization of alkynes/nitrile insertion/cyclization tandem sequence in a microchannel reactor. This novel protocol features extremely mild conditions, broad substrate scope and high reaction efficiency. In addition, a reasonable reaction mechanism was proposed based on control experiments.

UR - http://www.scopus.com/inward/record.url?scp=85178287755&partnerID=8YFLogxK

U2 - 10.1039/d3qo01508d

DO - 10.1039/d3qo01508d

M3 - 文章

AN - SCOPUS:85178287755

SN - 2052-4110

VL - 11

SP - 83

EP - 88

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 1

ER -

Synthesis of imidazo[1,2-a]pyridinones via a visible light-photocatalyzed functionalization of alkynes/nitrile insertion/cyclization tandem sequence using micro-flow technology

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