Synthesis of Phenanthridinones by Palladium-Catalyzed Cyclization of N -Aryl-2-aminopyridines with 2-Iodobenzoic Acids in Water

Xiaojuan Ding; Lei Zhang; Yiyang Mao; Binsen Rong; Ning Zhu; Jindian Duan; Kai Guo

doi:10.1055/s-0039-1691538

Synthesis of Phenanthridinones by Palladium-Catalyzed Cyclization of N -Aryl-2-aminopyridines with 2-Iodobenzoic Acids in Water

Xiaojuan Ding, Lei Zhang, Yiyang Mao, Binsen Rong, Ning Zhu, Jindian Duan, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The first Pd-catalyzed cyclization of N -aryl-2-aminopyridines with 2-iodobenzoic acids for the synthesis of phenanthridinones through C-H bond activation under very low catalyst loadings (down to 0.1 mol% Pd) in water is reported. This protocol features a broad substrate scope and provides easy efficient access to various phenanthridinones.

Original language	English
Article number	st-2019-l0548-l
Pages (from-to)	280-284
Number of pages	5
Journal	Synlett
Volume	31
Issue number	3
DOIs	https://doi.org/10.1055/s-0039-1691538
State	Published - 2020

Keywords

arylaminopyridines
cyclization
iodobenzoic acids
palladium catalysis
phenanthridinones

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10.1055/s-0039-1691538

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title = "Synthesis of Phenanthridinones by Palladium-Catalyzed Cyclization of N -Aryl-2-aminopyridines with 2-Iodobenzoic Acids in Water",

abstract = "The first Pd-catalyzed cyclization of N -aryl-2-aminopyridines with 2-iodobenzoic acids for the synthesis of phenanthridinones through C-H bond activation under very low catalyst loadings (down to 0.1 mol% Pd) in water is reported. This protocol features a broad substrate scope and provides easy efficient access to various phenanthridinones.",

keywords = "arylaminopyridines, cyclization, iodobenzoic acids, palladium catalysis, phenanthridinones",

author = "Xiaojuan Ding and Lei Zhang and Yiyang Mao and Binsen Rong and Ning Zhu and Jindian Duan and Kai Guo",

year = "2020",

doi = "10.1055/s-0039-1691538",

language = "英语",

volume = "31",

pages = "280--284",

journal = "Synlett",

issn = "0936-5214",

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TY - JOUR

T1 - Synthesis of Phenanthridinones by Palladium-Catalyzed Cyclization of N -Aryl-2-aminopyridines with 2-Iodobenzoic Acids in Water

AU - Ding, Xiaojuan

AU - Zhang, Lei

AU - Mao, Yiyang

AU - Rong, Binsen

AU - Zhu, Ning

AU - Duan, Jindian

AU - Guo, Kai

PY - 2020

Y1 - 2020

N2 - The first Pd-catalyzed cyclization of N -aryl-2-aminopyridines with 2-iodobenzoic acids for the synthesis of phenanthridinones through C-H bond activation under very low catalyst loadings (down to 0.1 mol% Pd) in water is reported. This protocol features a broad substrate scope and provides easy efficient access to various phenanthridinones.

AB - The first Pd-catalyzed cyclization of N -aryl-2-aminopyridines with 2-iodobenzoic acids for the synthesis of phenanthridinones through C-H bond activation under very low catalyst loadings (down to 0.1 mol% Pd) in water is reported. This protocol features a broad substrate scope and provides easy efficient access to various phenanthridinones.

KW - arylaminopyridines

KW - cyclization

KW - iodobenzoic acids

KW - palladium catalysis

KW - phenanthridinones

UR - http://www.scopus.com/inward/record.url?scp=85079423966&partnerID=8YFLogxK

U2 - 10.1055/s-0039-1691538

DO - 10.1055/s-0039-1691538

M3 - 文章

AN - SCOPUS:85079423966

SN - 0936-5214

VL - 31

SP - 280

EP - 284

JO - Synlett

JF - Synlett

IS - 3

M1 - st-2019-l0548-l

ER -

Synthesis of Phenanthridinones by Palladium-Catalyzed Cyclization of N -Aryl-2-aminopyridines with 2-Iodobenzoic Acids in Water

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Keywords

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