Synthesis of saracatinib

Hai Feng Shang; Yu Bin Wang; Da Min Zhao; Qi Zhang; Jin Xiong She

Synthesis of saracatinib

Hai Feng Shang, Yu Bin Wang, Da Min Zhao, Qi Zhang, Jin Xiong She

COLLEGE OF FOOD SCIENCE AND LIGHT INDUSTRY

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

Abstract

To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by ¹H-NMR and MS. This synthetic method was suitable for large-scale production.

Original language	English
Pages (from-to)	2363-2366
Number of pages	4
Journal	Chinese Journal of New Drugs
Volume	20
Issue number	23
State	Published - 15 Dec 2011

Keywords

Saracatinib
Synthesis
Tyrosine kinase inhibitor

Cite this

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title = "Synthesis of saracatinib",

abstract = "To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by 1H-NMR and MS. This synthetic method was suitable for large-scale production.",

keywords = "Saracatinib, Synthesis, Tyrosine kinase inhibitor",

author = "Shang, {Hai Feng} and Wang, {Yu Bin} and Zhao, {Da Min} and Qi Zhang and She, {Jin Xiong}",

year = "2011",

month = dec,

day = "15",

language = "英语",

volume = "20",

pages = "2363--2366",

journal = "Chinese Journal of New Drugs",

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number = "23",

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T1 - Synthesis of saracatinib

AU - Shang, Hai Feng

AU - Wang, Yu Bin

AU - Zhao, Da Min

AU - Zhang, Qi

AU - She, Jin Xiong

PY - 2011/12/15

Y1 - 2011/12/15

N2 - To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by 1H-NMR and MS. This synthetic method was suitable for large-scale production.

AB - To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by 1H-NMR and MS. This synthetic method was suitable for large-scale production.

KW - Saracatinib

KW - Synthesis

KW - Tyrosine kinase inhibitor

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M3 - 文章

AN - SCOPUS:84859491993

SN - 1003-3734

VL - 20

SP - 2363

EP - 2366

JO - Chinese Journal of New Drugs

JF - Chinese Journal of New Drugs

IS - 23

ER -

Synthesis of saracatinib

Abstract

Keywords

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