Systems and synthetic biotechnology for the production of polyunsaturated fatty acids

Wei Jian Wang, He Huang, Xiao Jun Ji

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations

Abstract

Polyunsaturated fatty acids (PUFAs), especially the omega-3 and -6 types, play an important role in human health and have consequently received extensive attention as nutritional ingredients. Oleaginous microorganisms, as an alternative source of PUFAs, can accumulate cellular PUFA-rich lipids. However, these microbial cells have evolved robust metabolic networks with hard-wired, tightly regulated lines of communication between molecular pathways, which poses a challenge to our metabolic pathway reconstruction efforts for increased PUFA production. Nowadays, the development of systems and synthetic biotechnology provides powerful new tools for us to better understand and remodel microbial metabolic networks. In this chapter, we will focus on these two technologies to summarize the strategies for microbial production of PUFAs and provide guidance for future study.

Original languageEnglish
Title of host publicationSystems and Synthetic Biotechnology for Production of Nutraceuticals
PublisherSpringer Singapore
Pages189-202
Number of pages14
ISBN (Electronic)9789811504464
ISBN (Print)9789811504457
DOIs
StatePublished - 1 Jan 2020

Keywords

  • Oleaginous microorganisms
  • Polyunsaturated fatty acids
  • Synthetic biotechnology
  • Systems biotechnology

Fingerprint

Dive into the research topics of 'Systems and synthetic biotechnology for the production of polyunsaturated fatty acids'. Together they form a unique fingerprint.

Cite this