TY - JOUR
T1 - The bioproduction of astaxanthin
T2 - A comprehensive review on the microbial synthesis and downstream extraction
AU - Zhou, Dawei
AU - Fei, Zhengyue
AU - Liu, Guannan
AU - Jiang, Yujia
AU - Jiang, Wankui
AU - Lin, Carol Sze Ki
AU - Zhang, Wenming
AU - Xin, Fengxue
AU - Jiang, Min
N1 - Publisher Copyright:
© 2024
PY - 2024/9
Y1 - 2024/9
N2 - Astaxanthin is a valuable orange-red carotenoid with wide applications in agriculture, food, cosmetics, pharmaceuticals and nutraceuticals areas. At present, the biological synthesis of astaxanthin mainly relies on Haematococcus pluvialis and Xanthophyllomyces dendrorhous. With the rapid development of synthetic biology, more recombinant microbial hosts have been genetically constructed for astaxanthin production including Escherichia coli, Saccharomyces cerevisiae and Yarrowia lipolytica. As multiple genes (15) were involved in the astaxanthin synthesis, it is particularly important to adopt different strategies to balance the metabolic flow towards the astaxanthin synthesis. Furthermore, astaxanthin is a fat-soluble compound stored intracellularly, hence efficient extraction methods are also essential for the economical production of astaxanthin. Several efficient and green extraction methods of astaxanthin have been reported in recent years, including the superfluid extraction, ionic liquid extraction and microwave-assisted extraction. Accordingly, this review will comprehensively introduce the advances on the astaxanthin production and extraction by using different microbial hosts and strategies to improve the astaxanthin synthesis and extraction efficiency.
AB - Astaxanthin is a valuable orange-red carotenoid with wide applications in agriculture, food, cosmetics, pharmaceuticals and nutraceuticals areas. At present, the biological synthesis of astaxanthin mainly relies on Haematococcus pluvialis and Xanthophyllomyces dendrorhous. With the rapid development of synthetic biology, more recombinant microbial hosts have been genetically constructed for astaxanthin production including Escherichia coli, Saccharomyces cerevisiae and Yarrowia lipolytica. As multiple genes (15) were involved in the astaxanthin synthesis, it is particularly important to adopt different strategies to balance the metabolic flow towards the astaxanthin synthesis. Furthermore, astaxanthin is a fat-soluble compound stored intracellularly, hence efficient extraction methods are also essential for the economical production of astaxanthin. Several efficient and green extraction methods of astaxanthin have been reported in recent years, including the superfluid extraction, ionic liquid extraction and microwave-assisted extraction. Accordingly, this review will comprehensively introduce the advances on the astaxanthin production and extraction by using different microbial hosts and strategies to improve the astaxanthin synthesis and extraction efficiency.
KW - Astaxanthin
KW - Astaxanthin extraction
KW - Chassis microbes
KW - Genetic modification
KW - Recombinant microorganism
KW - Synthetic biology
UR - http://www.scopus.com/inward/record.url?scp=85195189188&partnerID=8YFLogxK
U2 - 10.1016/j.biotechadv.2024.108392
DO - 10.1016/j.biotechadv.2024.108392
M3 - 文献综述
C2 - 38825214
AN - SCOPUS:85195189188
SN - 0734-9750
VL - 74
JO - Biotechnology Advances
JF - Biotechnology Advances
M1 - 108392
ER -