The copper-catalyzed synthesis of dihydrooxazoles from α,β-unsaturated ketoximes and activated ketones

Binsen Rong; Gaochen Xu; Huan Yan; Sai Zhang; Qinghuan Wu; Ning Zhu; Jindian Duan; Kai Guo

doi:10.1039/d1cc02422a

The copper-catalyzed synthesis of dihydrooxazoles from α,β-unsaturated ketoximes and activated ketones

Binsen Rong, Gaochen Xu, Huan Yan, Sai Zhang, Qinghuan Wu, Ning Zhu, Jindian Duan, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The first copper-catalyzed [3+2]-type condensation reaction of α,β-unsaturated ketoximes with activated ketones has been described for the synthesis of dihydrooxazoles, especially trifluoromethyl-decorated dihydrooxazoles. Notable features of this method include its broad substrate scope, good functional group tolerance, and simple operation.

Original language	English
Pages (from-to)	7272-7275
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	59
DOIs	https://doi.org/10.1039/d1cc02422a
State	Published - 28 Jul 2021

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abstract = "The first copper-catalyzed [3+2]-type condensation reaction of α,β-unsaturated ketoximes with activated ketones has been described for the synthesis of dihydrooxazoles, especially trifluoromethyl-decorated dihydrooxazoles. Notable features of this method include its broad substrate scope, good functional group tolerance, and simple operation.",

author = "Binsen Rong and Gaochen Xu and Huan Yan and Sai Zhang and Qinghuan Wu and Ning Zhu and Jindian Duan and Kai Guo",

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T1 - The copper-catalyzed synthesis of dihydrooxazoles from α,β-unsaturated ketoximes and activated ketones

AU - Rong, Binsen

AU - Xu, Gaochen

AU - Yan, Huan

AU - Zhang, Sai

AU - Wu, Qinghuan

AU - Zhu, Ning

AU - Duan, Jindian

AU - Guo, Kai

PY - 2021/7/28

Y1 - 2021/7/28

N2 - The first copper-catalyzed [3+2]-type condensation reaction of α,β-unsaturated ketoximes with activated ketones has been described for the synthesis of dihydrooxazoles, especially trifluoromethyl-decorated dihydrooxazoles. Notable features of this method include its broad substrate scope, good functional group tolerance, and simple operation.

AB - The first copper-catalyzed [3+2]-type condensation reaction of α,β-unsaturated ketoximes with activated ketones has been described for the synthesis of dihydrooxazoles, especially trifluoromethyl-decorated dihydrooxazoles. Notable features of this method include its broad substrate scope, good functional group tolerance, and simple operation.

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DO - 10.1039/d1cc02422a

M3 - 文章

C2 - 34195708

AN - SCOPUS:85111004627

SN - 1359-7345

VL - 57

SP - 7272

EP - 7275

JO - Chemical Communications

JF - Chemical Communications

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ER -

The copper-catalyzed synthesis of dihydrooxazoles from α,β-unsaturated ketoximes and activated ketones

Abstract

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