TY - JOUR
T1 - The ruthenium-catalyzed
T2 - Meta -selective C-H nitration of various azole ring-substituted arenes
AU - Zhang, Dong
AU - Gao, Di
AU - Cai, Jinlin
AU - Wu, Xiaoyu
AU - Qin, Hong
AU - Qiao, Kai
AU - Liu, Chengkou
AU - Fang, Zheng
AU - Guo, Kai
N1 - Publisher Copyright:
© 2019 The Royal Society of Chemistry.
PY - 2019
Y1 - 2019
N2 - The efficient ruthenium-catalyzed meta-selective CAr-H nitration of azole ring substituted arenes has been developed. In this work, Ru3(CO)12 was used as the catalyst, AgNO2 as the nitro source, HPcy3+·BF4- as the ligand, pivalic acid as the additive, and DCE as the solvent, and a wide spectrum of arenes bearing thiazole, pyrazolyl or removable oxazoline directing groups were tolerated in this meta-selective CAr-H nitration, affording the nitrated products in moderate to good yields. Moreover, this study reveals a gentler and environmentally friendly way to access meta-nitration arenes compared to the traditional process.
AB - The efficient ruthenium-catalyzed meta-selective CAr-H nitration of azole ring substituted arenes has been developed. In this work, Ru3(CO)12 was used as the catalyst, AgNO2 as the nitro source, HPcy3+·BF4- as the ligand, pivalic acid as the additive, and DCE as the solvent, and a wide spectrum of arenes bearing thiazole, pyrazolyl or removable oxazoline directing groups were tolerated in this meta-selective CAr-H nitration, affording the nitrated products in moderate to good yields. Moreover, this study reveals a gentler and environmentally friendly way to access meta-nitration arenes compared to the traditional process.
UR - http://www.scopus.com/inward/record.url?scp=85073484075&partnerID=8YFLogxK
U2 - 10.1039/c9ob01930h
DO - 10.1039/c9ob01930h
M3 - 文章
C2 - 31584058
AN - SCOPUS:85073484075
SN - 1477-0520
VL - 17
SP - 9065
EP - 9069
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 40
ER -