TY - JOUR
T1 - Therapeutic effect of strontium fructose 1,6-diphosphate (Sr-FDP) on glucocorticoid-induced osteoporosis in rats
AU - Zhang, Qi
AU - Ma, Bo
AU - Bai, Wen Xia
AU - Cheng, Yan Ping
AU - Ying, Han Jie
PY - 2008/10
Y1 - 2008/10
N2 - Aim: To study the therapeutic effect of strontium fructose 1, 6-diphosphate(Sr-FDP) on osteoporosis induced by glucocorticoid in rats. Methods: Osteoporosis rat model was developed successfully by intramuscular injection of dexamethasone for 8 weeks. Then treatment with oral dosing of Sr-FDP(110, mg/kg, 220 mg/kg and 440 mg/kg) was applied in the next 8 weeks measurement of bones and mineral content, bone mineral density (BMD), biomechanical properties of femur and lumbar vertebra, trabecular histomorphology, biochemical assays of serum were recorded after the termination of therapy. Results: Compare with model group, treatment using Sr-FDP of middle and high doses markedly increased BMD, Biomechanical properties, trabecular areas, and mineral appositional rates. Meanwhile, it significantly decreased the levels of serum Alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase 5b (TRACP 5b). Conclusion: Sr-FDP, which enhances bone formation and slow bone resorption, could prevent osteoporosis in rats induced by glucocorticoid.
AB - Aim: To study the therapeutic effect of strontium fructose 1, 6-diphosphate(Sr-FDP) on osteoporosis induced by glucocorticoid in rats. Methods: Osteoporosis rat model was developed successfully by intramuscular injection of dexamethasone for 8 weeks. Then treatment with oral dosing of Sr-FDP(110, mg/kg, 220 mg/kg and 440 mg/kg) was applied in the next 8 weeks measurement of bones and mineral content, bone mineral density (BMD), biomechanical properties of femur and lumbar vertebra, trabecular histomorphology, biochemical assays of serum were recorded after the termination of therapy. Results: Compare with model group, treatment using Sr-FDP of middle and high doses markedly increased BMD, Biomechanical properties, trabecular areas, and mineral appositional rates. Meanwhile, it significantly decreased the levels of serum Alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase 5b (TRACP 5b). Conclusion: Sr-FDP, which enhances bone formation and slow bone resorption, could prevent osteoporosis in rats induced by glucocorticoid.
KW - Dexamethasone
KW - Glucocorticoid
KW - Osteoporosis
KW - Strontium fructose 1,6-diphosphate (Sr-FDP)
UR - http://www.scopus.com/inward/record.url?scp=55749108830&partnerID=8YFLogxK
M3 - 文章
AN - SCOPUS:55749108830
SN - 1000-5048
VL - 39
SP - 442
EP - 446
JO - Journal of China Pharmaceutical University
JF - Journal of China Pharmaceutical University
IS - 5
ER -