Thermodynamic models for determination of the solid-liquid equilibrium of oxytocin in (acetonitrile+acetone) binary solvent mixtures

Qi Zhang; Yonghong Hu; Fei Shen; Wenge Yang; Gang Wu; Pengfei Gu; Yemin Yu

doi:10.1016/j.fluid.2015.08.009

Thermodynamic models for determination of the solid-liquid equilibrium of oxytocin in (acetonitrile+acetone) binary solvent mixtures

Qi Zhang, Yonghong Hu, Fei Shen, Wenge Yang, Gang Wu, Pengfei Gu, Yemin Yu

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In this paper, we focused on solubility and solution thermodynamics of oxytocin. By gravimetric method, the solubility of oxytocin was measured in (acetonitrile + acetone) binary solvent mixtures from 278.15 K to 328.15 K under atmosphere pressure. The solubility data were fitted using modified Apelblat equation, a variant of the combined nearly ideal binary solvent/Redich-Kister (CNIBS/R-K) model and Jouyban-Acree model. Computational results showed that the modified Apelblat equation was superior to the other two equations. In addition, the thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated by the van't Hoff analysis. The experimental results showed that acetonitrile could be used as an effective anti-solvent in the crystallization process.

Original language	English
Pages (from-to)	27-32
Number of pages	6
Journal	Fluid Phase Equilibria
Volume	408
DOIs	https://doi.org/10.1016/j.fluid.2015.08.009
State	Published - 25 Jan 2016

Keywords

Apelblat equation
CNIBS/R-K
Jouyban-Acree model
Oxytocin
Van't Hoff analysis

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10.1016/j.fluid.2015.08.009

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title = "Thermodynamic models for determination of the solid-liquid equilibrium of oxytocin in (acetonitrile+acetone) binary solvent mixtures",

abstract = "In this paper, we focused on solubility and solution thermodynamics of oxytocin. By gravimetric method, the solubility of oxytocin was measured in (acetonitrile + acetone) binary solvent mixtures from 278.15 K to 328.15 K under atmosphere pressure. The solubility data were fitted using modified Apelblat equation, a variant of the combined nearly ideal binary solvent/Redich-Kister (CNIBS/R-K) model and Jouyban-Acree model. Computational results showed that the modified Apelblat equation was superior to the other two equations. In addition, the thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated by the van't Hoff analysis. The experimental results showed that acetonitrile could be used as an effective anti-solvent in the crystallization process.",

keywords = "Apelblat equation, CNIBS/R-K, Jouyban-Acree model, Oxytocin, Van't Hoff analysis",

author = "Qi Zhang and Yonghong Hu and Fei Shen and Wenge Yang and Gang Wu and Pengfei Gu and Yemin Yu",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2016",

month = jan,

day = "25",

doi = "10.1016/j.fluid.2015.08.009",

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volume = "408",

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T1 - Thermodynamic models for determination of the solid-liquid equilibrium of oxytocin in (acetonitrile+acetone) binary solvent mixtures

AU - Zhang, Qi

AU - Hu, Yonghong

AU - Shen, Fei

AU - Yang, Wenge

AU - Wu, Gang

AU - Gu, Pengfei

AU - Yu, Yemin

PY - 2016/1/25

Y1 - 2016/1/25

N2 - In this paper, we focused on solubility and solution thermodynamics of oxytocin. By gravimetric method, the solubility of oxytocin was measured in (acetonitrile + acetone) binary solvent mixtures from 278.15 K to 328.15 K under atmosphere pressure. The solubility data were fitted using modified Apelblat equation, a variant of the combined nearly ideal binary solvent/Redich-Kister (CNIBS/R-K) model and Jouyban-Acree model. Computational results showed that the modified Apelblat equation was superior to the other two equations. In addition, the thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated by the van't Hoff analysis. The experimental results showed that acetonitrile could be used as an effective anti-solvent in the crystallization process.

AB - In this paper, we focused on solubility and solution thermodynamics of oxytocin. By gravimetric method, the solubility of oxytocin was measured in (acetonitrile + acetone) binary solvent mixtures from 278.15 K to 328.15 K under atmosphere pressure. The solubility data were fitted using modified Apelblat equation, a variant of the combined nearly ideal binary solvent/Redich-Kister (CNIBS/R-K) model and Jouyban-Acree model. Computational results showed that the modified Apelblat equation was superior to the other two equations. In addition, the thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated by the van't Hoff analysis. The experimental results showed that acetonitrile could be used as an effective anti-solvent in the crystallization process.

KW - Apelblat equation

KW - CNIBS/R-K

KW - Jouyban-Acree model

KW - Oxytocin

KW - Van't Hoff analysis

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DO - 10.1016/j.fluid.2015.08.009

M3 - 文章

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SN - 0378-3812

VL - 408

SP - 27

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JO - Fluid Phase Equilibria

JF - Fluid Phase Equilibria

ER -

Thermodynamic models for determination of the solid-liquid equilibrium of oxytocin in (acetonitrile+acetone) binary solvent mixtures

Abstract

Keywords

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