Thermodynamic models for determination of the solubility of omeprazole sulfide in (ethanol+ethyl acetate) binary solvent mixtures

Qirun Guo; Yonghong Hu; Wenge Yang; Tuan Zhang; Keyi Wu; Shouhai Yang; Ying Shi

doi:10.1016/j.fluid.2015.07.038

Thermodynamic models for determination of the solubility of omeprazole sulfide in (ethanol+ethyl acetate) binary solvent mixtures

Qirun Guo, Yonghong Hu, Wenge Yang, Tuan Zhang, Keyi Wu, Shouhai Yang, Ying Shi

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The solubility of omeprazole sulfide in (ethanol + ethyl acetate) binary solvent mixtures was measured within the temperature range from 277.65 to 333.15. K. The experimental data were fitted using CNIBS/R-K equation and the Jouyban-Acree equation, respectively. All the two equations were proven to give good representations of the experimental values. Computational results showed that the CNIBS/R-K equation was superior to the other equation. The thermodynamic properties of the solution process, including the Gibbs free energy, enthalpy and entropy, were calculated by the van't Hoff analysis. The values of both the enthalpy change and the standard molar Gibbs free energy change of solution were positive, which indicated that the process was endothermic.

Original language	English
Pages (from-to)	21-26
Number of pages	6
Journal	Fluid Phase Equilibria
Volume	406
DOIs	https://doi.org/10.1016/j.fluid.2015.07.038
State	Published - 5 Nov 2015

Keywords

Binary solvent
Omeprazole sulfide
Purification
Solubility
Solution thermodynamics

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10.1016/j.fluid.2015.07.038

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title = "Thermodynamic models for determination of the solubility of omeprazole sulfide in (ethanol+ethyl acetate) binary solvent mixtures",

abstract = "The solubility of omeprazole sulfide in (ethanol + ethyl acetate) binary solvent mixtures was measured within the temperature range from 277.65 to 333.15. K. The experimental data were fitted using CNIBS/R-K equation and the Jouyban-Acree equation, respectively. All the two equations were proven to give good representations of the experimental values. Computational results showed that the CNIBS/R-K equation was superior to the other equation. The thermodynamic properties of the solution process, including the Gibbs free energy, enthalpy and entropy, were calculated by the van't Hoff analysis. The values of both the enthalpy change and the standard molar Gibbs free energy change of solution were positive, which indicated that the process was endothermic.",

keywords = "Binary solvent, Omeprazole sulfide, Purification, Solubility, Solution thermodynamics",

author = "Qirun Guo and Yonghong Hu and Wenge Yang and Tuan Zhang and Keyi Wu and Shouhai Yang and Ying Shi",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

month = nov,

day = "5",

doi = "10.1016/j.fluid.2015.07.038",

language = "英语",

volume = "406",

pages = "21--26",

journal = "Fluid Phase Equilibria",

issn = "0378-3812",

publisher = "Elsevier B.V.",

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T1 - Thermodynamic models for determination of the solubility of omeprazole sulfide in (ethanol+ethyl acetate) binary solvent mixtures

AU - Guo, Qirun

AU - Hu, Yonghong

AU - Yang, Wenge

AU - Zhang, Tuan

AU - Wu, Keyi

AU - Yang, Shouhai

AU - Shi, Ying

PY - 2015/11/5

Y1 - 2015/11/5

N2 - The solubility of omeprazole sulfide in (ethanol + ethyl acetate) binary solvent mixtures was measured within the temperature range from 277.65 to 333.15. K. The experimental data were fitted using CNIBS/R-K equation and the Jouyban-Acree equation, respectively. All the two equations were proven to give good representations of the experimental values. Computational results showed that the CNIBS/R-K equation was superior to the other equation. The thermodynamic properties of the solution process, including the Gibbs free energy, enthalpy and entropy, were calculated by the van't Hoff analysis. The values of both the enthalpy change and the standard molar Gibbs free energy change of solution were positive, which indicated that the process was endothermic.

AB - The solubility of omeprazole sulfide in (ethanol + ethyl acetate) binary solvent mixtures was measured within the temperature range from 277.65 to 333.15. K. The experimental data were fitted using CNIBS/R-K equation and the Jouyban-Acree equation, respectively. All the two equations were proven to give good representations of the experimental values. Computational results showed that the CNIBS/R-K equation was superior to the other equation. The thermodynamic properties of the solution process, including the Gibbs free energy, enthalpy and entropy, were calculated by the van't Hoff analysis. The values of both the enthalpy change and the standard molar Gibbs free energy change of solution were positive, which indicated that the process was endothermic.

KW - Binary solvent

KW - Omeprazole sulfide

KW - Purification

KW - Solubility

KW - Solution thermodynamics

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U2 - 10.1016/j.fluid.2015.07.038

DO - 10.1016/j.fluid.2015.07.038

M3 - 文章

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SN - 0378-3812

VL - 406

SP - 21

EP - 26

JO - Fluid Phase Equilibria

JF - Fluid Phase Equilibria

ER -

Thermodynamic models for determination of the solubility of omeprazole sulfide in (ethanol+ethyl acetate) binary solvent mixtures

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Keywords

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