Transition-metal-free regioselective and stereoselective C(sp²)-C(sp³) coupling of enamides with ethers or alkanes via photoredox-catalyzed cross-dehydrogenative coupling reactions

A generally applicable and robust regio- and stereoselective cross-dehydrogenative-coupling of enamides with ethers or alkanes via transition-metal-free photoredox-catalysis under environmentally benign and atom economic conditions is demonstrated. The visible-light-induced transformations proceed smoothly with the aid of non-expensive and non-poisonous organic dyes, forging geometrically defined and synthetically paramount β-alkylated enamides with broad substituent diversity and functional group compatibility.