Ultrabright Green-Emissive Nanodots for Precise Biological Visualization

Yuxin Guo, Zihao Wang, Yu Chen, Furong Chao, Yin Xu, Lu Lu Qu, Fu Gen Wu, Xiaochen Dong

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Developing general methods to fabricate water-dispersible and biocompatible fluorescent probes will promote different biological visualization applications. Herein, we report a metal-facilitated method to fabricate ultrabright green-emissive nanodots via the one-step solvothermal treatment of rose bengal, ethanol, and various metal ions. These metal-doped nanodots show good water dispersity, ultrahigh photoluminescence quantum yields (PLQYs) (e.g., the PLQY of Fe-doped nanodots (FeNDs) was ∼97%), and low phototoxicity. Owing to the coordination effect of metal ions, the FeNDs realize glutathione detection with outstanding properties. Benefiting from the high endoplasmic reticulum (ER) affinity of the chloride group, the FeNDs can act as an ER tracker with long ER imaging capacity (FeNDs: >24 h; commercial ER tracker: ∼1 h) and superb photostability and can achieve tissue visualization in living Caenorhabditis elegans. The metal-doped nanodots represent a general nanodot preparation method and may shed new light on diverse biological visualization uses.

Original languageEnglish
Pages (from-to)2264-2272
Number of pages9
JournalNano Letters
Volume24
Issue number7
DOIs
StatePublished - 21 Feb 2024

Keywords

  • biological imaging
  • carbon dot
  • endoplasmic reticulum imaging
  • glutathione detection
  • metal-doped nanodots

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