Water-Tolerant ortho-Acylation of Phenols

Jie Sheng Tian; Yu He; Zhi Yuan Gao; Xu Liu; Shuang Feng Dong; Peng Wu; Teck Peng Loh

doi:10.1021/acs.orglett.1c02583

Water-Tolerant ortho-Acylation of Phenols

Jie Sheng Tian, Yu He, Zhi Yuan Gao, Xu Liu, Shuang Feng Dong, Peng Wu, Teck Peng Loh

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

Original language	English
Pages (from-to)	6594-6598
Number of pages	5
Journal	Organic Letters
Volume	23
Issue number	16
DOIs	https://doi.org/10.1021/acs.orglett.1c02583
State	Published - 20 Aug 2021

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10.1021/acs.orglett.1c02583

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title = "Water-Tolerant ortho-Acylation of Phenols",

abstract = "A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.",

author = "Tian, {Jie Sheng} and Yu He and Gao, {Zhi Yuan} and Xu Liu and Dong, {Shuang Feng} and Peng Wu and Loh, {Teck Peng}",

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doi = "10.1021/acs.orglett.1c02583",

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T1 - Water-Tolerant ortho-Acylation of Phenols

AU - Tian, Jie Sheng

AU - He, Yu

AU - Gao, Zhi Yuan

AU - Liu, Xu

AU - Dong, Shuang Feng

AU - Wu, Peng

AU - Loh, Teck Peng

PY - 2021/8/20

Y1 - 2021/8/20

N2 - A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

AB - A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

UR - http://www.scopus.com/inward/record.url?scp=85113928542&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.1c02583

DO - 10.1021/acs.orglett.1c02583

M3 - 文章

C2 - 34378942

AN - SCOPUS:85113928542

SN - 1523-7060

VL - 23

SP - 6594

EP - 6598

JO - Organic Letters

JF - Organic Letters

IS - 16

ER -

Water-Tolerant ortho-Acylation of Phenols

Abstract

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