α-Amino Acetal: A Synthetic Intermediate for the Construction of Aza-Polycycles

Duan Yang Liu; Si Mao Zhu; Rui Qi Li; Jie Sheng Tian; Teck Peng Loh

doi:10.1021/acs.orglett.9b02240

α-Amino Acetal: A Synthetic Intermediate for the Construction of Aza-Polycycles

Duan Yang Liu, Si Mao Zhu, Rui Qi Li, Jie Sheng Tian, Teck Peng Loh

化学与分子工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

10 引用（Scopus）

摘要

One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.

源语言	英语
页（从-至）	6357-6360
页数	4
期刊	Organic Letters
卷	21
期	16
DOI	https://doi.org/10.1021/acs.orglett.9b02240
出版状态	已出版 - 16 8月 2019

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abstract = "One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.",

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AU - Liu, Duan Yang

AU - Zhu, Si Mao

AU - Li, Rui Qi

AU - Tian, Jie Sheng

AU - Loh, Teck Peng

PY - 2019/8/16

Y1 - 2019/8/16

N2 - One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.

AB - One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.

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α-Amino Acetal: A Synthetic Intermediate for the Construction of Aza-Polycycles

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