以吗啉与环氧乙烷为原料的无催化剂 连续快速合成吗啉乙醇工艺硏究

In order to solve the problems of the synthesis of morpholine ethanol from morpholine and ethylene oxide, such as low yield, long reaction time, poor safety and the use of catalysts, in a microchannel reactor consisting of SIMM-V2 micro-mixer and a stainless steel tube, the continuous and rapid preparation of morpholine ethanol was studied, and the effects of reaction temperature, residence time, system pressure,molar ratio of raw materials and flow rate were investigated. The results showed that the yield of the reactor was almost equal comparable to that of the kettle reactor under the condition of no catalyst and shorter reaction time. With the increase of reaction temperature, residence time, and molar ratio, the yield of the product increased first and then decreased, there was a wide window of reaction conditions,that was, given a certain condition, the other conditions could be adjusted to obtain the same yield. Under typical reaction conditions, such as a temperature of 150 ∗C , a morpholine to ethylene oxide molar ratio of 1 : 1. 08, a residence time of 3 min,a total flow rate a 1 mL/min,and a system pressure of 2. 5 MPa,the conversion of morpholine could reach 99. 55%, and the selectivity of morpholine ethanol was 97. 1%, which was much higher than that of the batch reaction.