酶催化原子转移自由基聚合

Atom transfer radical polymerization (ATRP) is an important method for preparing polymers with controllable molecular weight and polydispersity. However, due to the complex oxygen removal steps, metal catalysts residue, and limited monomer scope, it is difficult for ATRP to be widely used in the large-scale preparation of functionalized polymers/copolymers. With the development of enzyme-catalyzed polymerization, radical polymerization has made significant progress in efficient and convenient oxygen removal, expanding monomer scope, and the synthesis of polymers/copolymers with special (nano) structures. This review highlights the structure of enzymes and their catalytic mechanism in enzyme-catalyzed ATRP. Various enzyme/enzyme mimics catalysis system (including horseradish peroxidase, hemoglobin, heme, laccase, etc.) employed in ATRP are carefully summarized in order. Finally, the opportunities and challenges of enzyme-catalyzed ATRP are discussed for the further development in this field.