A highly sensitive and reusable electrochemical mercury biosensor based on tunable vertical single-walled carbon nanotubes and a target recycling strategy

Lei Shi, Yan Wang, Zhenyu Chu, Yu Yin, Danfeng Jiang, Jingyi Luo, Shiming Ding, Wanqin Jin

科研成果: 期刊稿件文章同行评审

45 引用 (Scopus)

摘要

In this work, a novel electrochemical Hg2+ biosensor with high sensitivity and excellent reusability was presented. The sensor was based on tunable vertical single-walled carbon nanotubes (v-SWCNTs) and a target recycling strategy. A facile and scalable approach involving the conformational regulation of self-assembled monolayers was established for the fabrication of v-SWCNTs with tailored orientation and homogeneity. The obtained v-SWCNTs exhibited superior properties including a large specific area, high electrical conductivity, and excellent substrate binding strength, opening up a wide horizon for advanced electrochemical applications. Meanwhile, an efficient Hg2+ recycling strategy was designed using exonuclease III. In this strategy, a trace amount of Hg2+ triggered consecutive nicking reactions, and numerous report probes were released to bind with v-SWCNTs through π-π interactions. Based on the innovative design, an ultralow detection limit of 3 fM (S/N = 3), a wide linear range from 10 fM to 1 μM, high selectivity, and good reliability were achieved for a Hg2+ assay in water and serum samples using the prepared biosensor. Besides, due to the reversibility of π-π interactions, the stable v-SWCNT interface was regenerated for 50 consecutive measurements without obvious signal loss, making it a promising candidate for routine and efficient Hg2+ monitoring.

源语言英语
页(从-至)1073-1080
页数8
期刊Journal of Materials Chemistry B
5
5
DOI
出版状态已出版 - 2017

指纹

探究 'A highly sensitive and reusable electrochemical mercury biosensor based on tunable vertical single-walled carbon nanotubes and a target recycling strategy' 的科研主题。它们共同构成独一无二的指纹。

引用此