TY - JOUR
T1 - A highly water-soluble triblock conjugated polymer for
T2 - In vivo NIR-II imaging and photothermal therapy of cancer
AU - Lu, Xiaomei
AU - Yuan, Pengcheng
AU - Zhang, Wansu
AU - Wu, Qi
AU - Wang, Xiaoxiao
AU - Zhao, Meng
AU - Sun, Pengfei
AU - Huang, Wei
AU - Fan, Quli
N1 - Publisher Copyright:
© 2018 The Royal Society of Chemistry.
PY - 2018/6/14
Y1 - 2018/6/14
N2 - Applications of the second near infrared (NIR) optical window (NIR-II, 1000-1700 nm) have received increasing attention with respect to reduced scattering and negligible auto-fluorescence, thus achieving a high signal-to-background ratio for pinpointing tumors compared with NIR-I imaging. Conjugated polymers have been applied in NIR-II imaging for their advantages, such as high molar extinction coefficient, wide emission wavelength, and ease of preparation. However, currently available conjugated polymer NIR-II agents suffer from a lack of water solubility. Hence, a highly water-soluble triblock conjugated polymer (POEGMA-b-PDPP-b-POEGMA) based on diketopyrrolopyrrole was successfully prepared with a high yield. The NIR-II imaging depth of the conjugated polymer was ∼7 mm, which is far beyond conventional NIR-I agents. Furthermore, the fluorescence quantum yield (QY) of POEGMA-b-PDPP-b-POEGMA reached up to 1.0%, which is higher than most reported NIR-II probes. This novel NIR-II conjugated polymer shows improved solubility (>10 mg mL-1) and greater dispersion in aqueous solution compared to those conventional conjugated polymers, due to the introduction of the water-soluble polymer POEGMA. With the help of high emission (>1000 nm), POEGMA-b-PDPP-b-POEGMA could efficiently realize the highly penetrable NIR-II imaging of tumors. In addition, POEGMA-b-PDPP-b-POEGMA could be a promising photothermal therapy agent to ablate tumors due to its high photothermal conversion efficiency (52%).
AB - Applications of the second near infrared (NIR) optical window (NIR-II, 1000-1700 nm) have received increasing attention with respect to reduced scattering and negligible auto-fluorescence, thus achieving a high signal-to-background ratio for pinpointing tumors compared with NIR-I imaging. Conjugated polymers have been applied in NIR-II imaging for their advantages, such as high molar extinction coefficient, wide emission wavelength, and ease of preparation. However, currently available conjugated polymer NIR-II agents suffer from a lack of water solubility. Hence, a highly water-soluble triblock conjugated polymer (POEGMA-b-PDPP-b-POEGMA) based on diketopyrrolopyrrole was successfully prepared with a high yield. The NIR-II imaging depth of the conjugated polymer was ∼7 mm, which is far beyond conventional NIR-I agents. Furthermore, the fluorescence quantum yield (QY) of POEGMA-b-PDPP-b-POEGMA reached up to 1.0%, which is higher than most reported NIR-II probes. This novel NIR-II conjugated polymer shows improved solubility (>10 mg mL-1) and greater dispersion in aqueous solution compared to those conventional conjugated polymers, due to the introduction of the water-soluble polymer POEGMA. With the help of high emission (>1000 nm), POEGMA-b-PDPP-b-POEGMA could efficiently realize the highly penetrable NIR-II imaging of tumors. In addition, POEGMA-b-PDPP-b-POEGMA could be a promising photothermal therapy agent to ablate tumors due to its high photothermal conversion efficiency (52%).
UR - http://www.scopus.com/inward/record.url?scp=85048090992&partnerID=8YFLogxK
U2 - 10.1039/c8py00215k
DO - 10.1039/c8py00215k
M3 - 文章
AN - SCOPUS:85048090992
SN - 1759-9954
VL - 9
SP - 3118
EP - 3126
JO - Polymer Chemistry
JF - Polymer Chemistry
IS - 22
ER -
