A two-step continuous synthesis of α-ketoamides and α-amino ketones from 2° benzylic alcohols using hydrogen peroxide as an economic and benign oxidant

Chengkou Liu, Zheng Fang, Zhao Yang, Qingwen Li, Shiyu Guo, Kai Guo

科研成果: 期刊稿件文章同行评审

26 引用 (Scopus)

摘要

A practical two-step synthesis of α-ketoamides and α-amino ketones via direct oxidative coupling between 2° benzylic alcohols and amines was developed. Hydrogen peroxide, an economic and environmentally friendly oxidant, was used, and a metal catalyst was unnecessary. Moreover, the continuous-flow technique was employed to increase the functional group tolerance, efficiency and safety.

源语言英语
页(从-至)25167-25172
页数6
期刊RSC Advances
6
30
DOI
出版状态已出版 - 2016

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