An enzyme cascade sensor with resistance to the inherent intermediate product by logic-controlled peroxidase mimic catalysis

Enzyme cascade sensors usually could not discriminate between the target and intermediate product. Herein, based on “AND” logic-controlled activation of the glucose oxidase-copper peroxide sensing system, enzyme cascade detection for glucose with resistance to inherently existing intermediate product H₂O₂was reported for the first time, which may provide a novel way for facilitating enzyme cascade sensing.