Asymmetric aza-BODIPY photosensitizer for photoacoustic/photothermal imaging-guided synergistic photodynamic/photothermal therapy

Xiaohong Ruan; Min Wei; Xiaoyu He; Leichen Wang; Dongliang Yang; Yu Cai; Jinjun Shao; Xiaochen Dong

doi:10.1016/j.colsurfb.2023.113547

Asymmetric aza-BODIPY photosensitizer for photoacoustic/photothermal imaging-guided synergistic photodynamic/photothermal therapy

Xiaohong Ruan, Min Wei, Xiaoyu He, Leichen Wang, Dongliang Yang, Yu Cai, Jinjun Shao, Xiaochen Dong

科研成果: 期刊稿件 › 文章 › 同行评审

5 引用（Scopus）

摘要

Cancer synergistic therapy usually shows improved therapeutic efficacy with low side effects. In this contribution, an aza-BODIPY-derived photosensitizer NBDP with asymmetric structure and the periphery phenyl ring modified with bromine atom was designed and synthesized for synergistic photothermal therapy (PTT) and photodynamic therapy (PDT). Photosensitizer NBDP exhibited good singlet oxygen (¹O₂) generation capacity (1.43 times higher than that of ICG), and NBDP NPs showed an outstanding photothermal conversion efficiency (η) of 46.0% under 660 nm photoirradiation. Guided by in vivo photoacoustic (PA) imaging, NBDP NPs were found to targetedly accumulate in the tumor tissues in 6 h. All results showed that the aza-BODIPY-derived photosensitizer NBDP had great potential for PA/photothermal imaging-guided synergistic PTT/PDT.

源语言	英语
文章编号	113547
期刊	Colloids and Surfaces B: Biointerfaces
卷	231
DOI	https://doi.org/10.1016/j.colsurfb.2023.113547
出版状态	已出版 - 11月 2023

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title = "Asymmetric aza-BODIPY photosensitizer for photoacoustic/photothermal imaging-guided synergistic photodynamic/photothermal therapy",

abstract = "Cancer synergistic therapy usually shows improved therapeutic efficacy with low side effects. In this contribution, an aza-BODIPY-derived photosensitizer NBDP with asymmetric structure and the periphery phenyl ring modified with bromine atom was designed and synthesized for synergistic photothermal therapy (PTT) and photodynamic therapy (PDT). Photosensitizer NBDP exhibited good singlet oxygen (1O2) generation capacity (1.43 times higher than that of ICG), and NBDP NPs showed an outstanding photothermal conversion efficiency (η) of 46.0% under 660 nm photoirradiation. Guided by in vivo photoacoustic (PA) imaging, NBDP NPs were found to targetedly accumulate in the tumor tissues in 6 h. All results showed that the aza-BODIPY-derived photosensitizer NBDP had great potential for PA/photothermal imaging-guided synergistic PTT/PDT.",

keywords = "Asymmetric aza-BODIPY, Photoacoustic imaging, Photodynamic, Photothermal",

author = "Xiaohong Ruan and Min Wei and Xiaoyu He and Leichen Wang and Dongliang Yang and Yu Cai and Jinjun Shao and Xiaochen Dong",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = nov,

doi = "10.1016/j.colsurfb.2023.113547",

language = "英语",

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TY - JOUR

T1 - Asymmetric aza-BODIPY photosensitizer for photoacoustic/photothermal imaging-guided synergistic photodynamic/photothermal therapy

AU - Ruan, Xiaohong

AU - Wei, Min

AU - He, Xiaoyu

AU - Wang, Leichen

AU - Yang, Dongliang

AU - Cai, Yu

AU - Shao, Jinjun

AU - Dong, Xiaochen

PY - 2023/11

Y1 - 2023/11

N2 - Cancer synergistic therapy usually shows improved therapeutic efficacy with low side effects. In this contribution, an aza-BODIPY-derived photosensitizer NBDP with asymmetric structure and the periphery phenyl ring modified with bromine atom was designed and synthesized for synergistic photothermal therapy (PTT) and photodynamic therapy (PDT). Photosensitizer NBDP exhibited good singlet oxygen (1O2) generation capacity (1.43 times higher than that of ICG), and NBDP NPs showed an outstanding photothermal conversion efficiency (η) of 46.0% under 660 nm photoirradiation. Guided by in vivo photoacoustic (PA) imaging, NBDP NPs were found to targetedly accumulate in the tumor tissues in 6 h. All results showed that the aza-BODIPY-derived photosensitizer NBDP had great potential for PA/photothermal imaging-guided synergistic PTT/PDT.

AB - Cancer synergistic therapy usually shows improved therapeutic efficacy with low side effects. In this contribution, an aza-BODIPY-derived photosensitizer NBDP with asymmetric structure and the periphery phenyl ring modified with bromine atom was designed and synthesized for synergistic photothermal therapy (PTT) and photodynamic therapy (PDT). Photosensitizer NBDP exhibited good singlet oxygen (1O2) generation capacity (1.43 times higher than that of ICG), and NBDP NPs showed an outstanding photothermal conversion efficiency (η) of 46.0% under 660 nm photoirradiation. Guided by in vivo photoacoustic (PA) imaging, NBDP NPs were found to targetedly accumulate in the tumor tissues in 6 h. All results showed that the aza-BODIPY-derived photosensitizer NBDP had great potential for PA/photothermal imaging-guided synergistic PTT/PDT.

KW - Asymmetric aza-BODIPY

KW - Photoacoustic imaging

KW - Photodynamic

KW - Photothermal

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U2 - 10.1016/j.colsurfb.2023.113547

DO - 10.1016/j.colsurfb.2023.113547

M3 - 文章

C2 - 37729797

AN - SCOPUS:85171332225

SN - 0927-7765

VL - 231

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

M1 - 113547

ER -

Asymmetric aza-BODIPY photosensitizer for photoacoustic/photothermal imaging-guided synergistic photodynamic/photothermal therapy

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