TY - JOUR
T1 - Biocompatible C-S bond construction for diarylmethyl thioethers
AU - Zhang, Zhenwei
AU - Tao, Xu
AU - Ju, Chengyang
AU - Gao, Cuiqing
AU - Loh, Teck Peng
AU - Xie, Peizhong
N1 - Publisher Copyright:
© 2025 Fudan University
PY - 2025
Y1 - 2025
N2 - We have developed a sustainable method for the construction of C-S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs) as partners, this methodology allows efficient preparation of diarylmethyl thioethers with broad thiol compatibility, exceptional chemo-selectivity, and stability. This process facilitates the large-scale preparation of diarylmethyl thioethers, and also enhances applications in bioconjugation, providing valuable tools for drug development and biomolecular engineering.
AB - We have developed a sustainable method for the construction of C-S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs) as partners, this methodology allows efficient preparation of diarylmethyl thioethers with broad thiol compatibility, exceptional chemo-selectivity, and stability. This process facilitates the large-scale preparation of diarylmethyl thioethers, and also enhances applications in bioconjugation, providing valuable tools for drug development and biomolecular engineering.
KW - Biocompatible conditions
KW - Bioconjugation
KW - C-S bond construction
KW - Diarylmethyl thioethers
UR - http://www.scopus.com/inward/record.url?scp=105000043992&partnerID=8YFLogxK
U2 - 10.1016/j.gresc.2025.03.002
DO - 10.1016/j.gresc.2025.03.002
M3 - 文章
AN - SCOPUS:105000043992
SN - 2666-5549
JO - Green Synthesis and Catalysis
JF - Green Synthesis and Catalysis
ER -