Biocompatible C-S bond construction for diarylmethyl thioethers

Zhenwei Zhang, Xu Tao, Chengyang Ju, Cuiqing Gao, Teck Peng Loh, Peizhong Xie

科研成果: 期刊稿件文章同行评审

摘要

We have developed a sustainable method for the construction of C-S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs) as partners, this methodology allows efficient preparation of diarylmethyl thioethers with broad thiol compatibility, exceptional chemo-selectivity, and stability. This process facilitates the large-scale preparation of diarylmethyl thioethers, and also enhances applications in bioconjugation, providing valuable tools for drug development and biomolecular engineering.

源语言英语
期刊Green Synthesis and Catalysis
DOI
出版状态已接受/待刊 - 2025

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