TY - JOUR
T1 - Biotechnological potential and applications of microbial consortia
AU - Qian, Xiujuan
AU - Chen, Lin
AU - Sui, Yuan
AU - Chen, Chong
AU - Zhang, Wenming
AU - Zhou, Jie
AU - Dong, Weiliang
AU - Jiang, Min
AU - Xin, Fengxue
AU - Ochsenreither, Katrin
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Recent advances in microbial consortia present a valuable approach for expanding the scope of metabolic engineering. Systems biology enable thorough understanding of diverse physiological processes of cells and their interactions, which in turn offers insights into the optimal design of synthetic microbial consortia. Yet, the study of synthetic microbial consortia is still in early infancy, facing many unknowns and challenges in intercellular communication and construction of stable and controllable microbial consortia systems. In this review, we comprehensively discussed the recent application of defined microbial consortia in the fields of human health monitoring and medicine exploitation, valuable compounds synthesis, consolidated bioprocessing of lignocellulosic materials and environmental bioremediation. Moreover, the outstanding challenges and future directions to advance the development of high-efficient, stable and controllable synthetic microbial consortia were highlighted.
AB - Recent advances in microbial consortia present a valuable approach for expanding the scope of metabolic engineering. Systems biology enable thorough understanding of diverse physiological processes of cells and their interactions, which in turn offers insights into the optimal design of synthetic microbial consortia. Yet, the study of synthetic microbial consortia is still in early infancy, facing many unknowns and challenges in intercellular communication and construction of stable and controllable microbial consortia systems. In this review, we comprehensively discussed the recent application of defined microbial consortia in the fields of human health monitoring and medicine exploitation, valuable compounds synthesis, consolidated bioprocessing of lignocellulosic materials and environmental bioremediation. Moreover, the outstanding challenges and future directions to advance the development of high-efficient, stable and controllable synthetic microbial consortia were highlighted.
KW - Consolidated bioprocessing
KW - Environment bio-remediation
KW - Human health supervision
KW - Microbial consortia application
KW - Microbial consortia construction challenges
KW - Valuable compounds synthesis
UR - http://www.scopus.com/inward/record.url?scp=85077159489&partnerID=8YFLogxK
U2 - 10.1016/j.biotechadv.2019.107500
DO - 10.1016/j.biotechadv.2019.107500
M3 - 文献综述
C2 - 31862233
AN - SCOPUS:85077159489
SN - 0734-9750
VL - 40
JO - Biotechnology Advances
JF - Biotechnology Advances
M1 - 107500
ER -
