Catalytic base-controlled regiodivergent heteronucleophilic hydrofunctionalization of β,γ-unsaturated amides

Yao Zhao; Jiacheng Rui; Qiang Du; Rizhi Chen; Ying Zhan; Xintao Zheng; Xiaojin Wu

doi:10.1039/d1cc03440e

Catalytic base-controlled regiodivergent heteronucleophilic hydrofunctionalization of β,γ-unsaturated amides

Yao Zhao, Jiacheng Rui, Qiang Du, Rizhi Chen, Ying Zhan, Xintao Zheng, Xiaojin Wu

化工学院

Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

6 引用（Scopus）

摘要

A general catalytic base-controlled regiodivergent nucleophilic hydrofunctionalization of both terminal and internal β,γ-unsaturated amides has been reported. The atom-economical addition of various S/P-based nucleophiles was also exclusively chemoselective. More than 60 branched or linear hetero-substituted aliphatic amides were synthesized from common starting materials under transition-metal-free conditions. Preliminary mechanistic studies are consistent with our proposed divergent catalytic cycles.

源语言	英语
页（从-至）	9756-9759
页数	4
期刊	Chemical Communications
卷	57
期	76
DOI	https://doi.org/10.1039/d1cc03440e
出版状态	已出版 - 28 9月 2021

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10.1039/d1cc03440e

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abstract = "A general catalytic base-controlled regiodivergent nucleophilic hydrofunctionalization of both terminal and internal β,γ-unsaturated amides has been reported. The atom-economical addition of various S/P-based nucleophiles was also exclusively chemoselective. More than 60 branched or linear hetero-substituted aliphatic amides were synthesized from common starting materials under transition-metal-free conditions. Preliminary mechanistic studies are consistent with our proposed divergent catalytic cycles.",

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T1 - Catalytic base-controlled regiodivergent heteronucleophilic hydrofunctionalization of β,γ-unsaturated amides

AU - Zhao, Yao

AU - Rui, Jiacheng

AU - Du, Qiang

AU - Chen, Rizhi

AU - Zhan, Ying

AU - Zheng, Xintao

AU - Wu, Xiaojin

PY - 2021/9/28

Y1 - 2021/9/28

N2 - A general catalytic base-controlled regiodivergent nucleophilic hydrofunctionalization of both terminal and internal β,γ-unsaturated amides has been reported. The atom-economical addition of various S/P-based nucleophiles was also exclusively chemoselective. More than 60 branched or linear hetero-substituted aliphatic amides were synthesized from common starting materials under transition-metal-free conditions. Preliminary mechanistic studies are consistent with our proposed divergent catalytic cycles.

AB - A general catalytic base-controlled regiodivergent nucleophilic hydrofunctionalization of both terminal and internal β,γ-unsaturated amides has been reported. The atom-economical addition of various S/P-based nucleophiles was also exclusively chemoselective. More than 60 branched or linear hetero-substituted aliphatic amides were synthesized from common starting materials under transition-metal-free conditions. Preliminary mechanistic studies are consistent with our proposed divergent catalytic cycles.

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U2 - 10.1039/d1cc03440e

DO - 10.1039/d1cc03440e

M3 - 文章

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AN - SCOPUS:85115760234

SN - 1359-7345

VL - 57

SP - 9756

EP - 9759

JO - Chemical Communications

JF - Chemical Communications

IS - 76

ER -

Catalytic base-controlled regiodivergent heteronucleophilic hydrofunctionalization of β,γ-unsaturated amides

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