Catalytically Asymmetric Synthesis of 1,3-Bis(silyl)propenes via Copper-Catalyzed Double Proto-Silylations of Polar Enynes

Fei Fan Meng, Jia Hao Xie, Yun He Xu, Teck Peng Loh

科研成果: 期刊稿件文章同行评审

25 引用 (Scopus)

摘要

A copper-catalyzed double proto-silylations of electron-deficient conjugated enynes to synthesize functional bis(silyl)propenes was developed. Under mild reaction conditions, the silylboronate PhMe2Si-Bpin reacts with the enynes via cascade proto-silylations and yields the corresponding Z-specific bis(silyl)propene products in up to 98% yield and 95% ee. In addition, the enantioselective synthesis of these compounds was also achieved by using enantiopure pyridine-oxazoline-based ligand.

源语言英语
页(从-至)5306-5312
页数7
期刊ACS Catalysis
8
6
DOI
出版状态已出版 - 1 6月 2018
已对外发布

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