Chemically functionalized surface patterning

Patterning substrates with versatile chemical functionalities from micro- to nanometer scale is a long-standing and interesting topic. This review provides an overview of a range of techniques commonly used for surface patterning. The first section briefly introduces conventional micropatterning tools, such as photolithography and microcontact printing. The second section focuses on the currently used nanolithographic techniques, for example, scanning probe lithography (SPL), and their applications in surface patterning. Their advantages and disadvantages are also demonstrated. In the last section, dip-pen nanolithography (DPN) is emphatically illustrated, with a particular stress on the patterning and applications of biomolecules. Patterning substrates with versatile chemical functionalities from micro- to nanometer scale is a long-standing and interesting topic. In this review, a variety of methods are introduced for patterning small molecules, biomolecules, polymers, and nanoparticles.