Colorimetric and fluorometric detection of neomycin based on conjugated polydiacetylene supramolecules

Guodong Zhou; Fang Wang; Huilin Wang; Srinivasulu Kambam; Xiaoqiang Chen

doi:10.1002/marc.201200837

Colorimetric and fluorometric detection of neomycin based on conjugated polydiacetylene supramolecules

Guodong Zhou, Fang Wang, Huilin Wang, Srinivasulu Kambam, Xiaoqiang Chen

化工学院

Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

40 引用（Scopus）

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Utilizing the colorimetric and fluorogenic changes, a system based on polydiacetylenes (PDAs) is developed for the detection of neomycin. The PDA supramolecules polymerized from the mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10,12-diynamide (PCDA-AP) and pentacosa-10,12- diynoic acid (PCDA) at an optimized ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin. The detection limit for neomycin is estimated to be 2.55 × 10^-7 M by the fluorogenic method. The optical changes induced by neomycin can be attributed to the disruption of the hydrogen bonding between phenol and carboxylic acid from PCDA-AP and PCDA. Polydiacetylene supramolecules polymerized from a mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10, 12-diynamide and pentacosa-10,12-diynoic acid at an optimal ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin.

源语言	英语
页（从-至）	944-948
页数	5
期刊	Macromolecular Rapid Communications
卷	34
期	11
DOI	https://doi.org/10.1002/marc.201200837
出版状态	已出版 - 13 6月 2013

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abstract = "Utilizing the colorimetric and fluorogenic changes, a system based on polydiacetylenes (PDAs) is developed for the detection of neomycin. The PDA supramolecules polymerized from the mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10,12-diynamide (PCDA-AP) and pentacosa-10,12- diynoic acid (PCDA) at an optimized ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin. The detection limit for neomycin is estimated to be 2.55 × 10-7 M by the fluorogenic method. The optical changes induced by neomycin can be attributed to the disruption of the hydrogen bonding between phenol and carboxylic acid from PCDA-AP and PCDA. Polydiacetylene supramolecules polymerized from a mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10, 12-diynamide and pentacosa-10,12-diynoic acid at an optimal ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin.",

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AU - Chen, Xiaoqiang

PY - 2013/6/13

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AB - Utilizing the colorimetric and fluorogenic changes, a system based on polydiacetylenes (PDAs) is developed for the detection of neomycin. The PDA supramolecules polymerized from the mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10,12-diynamide (PCDA-AP) and pentacosa-10,12- diynoic acid (PCDA) at an optimized ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin. The detection limit for neomycin is estimated to be 2.55 × 10-7 M by the fluorogenic method. The optical changes induced by neomycin can be attributed to the disruption of the hydrogen bonding between phenol and carboxylic acid from PCDA-AP and PCDA. Polydiacetylene supramolecules polymerized from a mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10, 12-diynamide and pentacosa-10,12-diynoic acid at an optimal ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin.

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Colorimetric and fluorometric detection of neomycin based on conjugated polydiacetylene supramolecules

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