Combining Fluoroalkylation and Defluorination to Enable Formal [3 + 2 + 1] Heteroannulation by Using Visible-Light Photoredox Organocatalysis

Xue Qiang Chu; Ting Xie; Lin Li; Danhua Ge; Zhi Liang Shen; Teck Peng Loh

doi:10.1021/acs.orglett.8b00963

Combining Fluoroalkylation and Defluorination to Enable Formal [3 + 2 + 1] Heteroannulation by Using Visible-Light Photoredox Organocatalysis

Xue Qiang Chu, Ting Xie, Lin Li, Danhua Ge, Zhi Liang Shen, Teck Peng Loh

化学与分子工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

47 引用（Scopus）

摘要

A metal-free, visible-light photoredox-catalyzed three-component [3 + 2 + 1] heteroannulation for accessing modular fluoroalkylated pyrimidines from readily available silyl enol ether, amidine, and fluoroalkyl halide is developed. This protocol distinguishes itself by broad functional group tolerance in a regioselective manner, which provides a complement to the existing methods for the construction of pharmaceutically and biologically active organofluorine compounds.

源语言	英语
页（从-至）	2749-2752
页数	4
期刊	Organic Letters
卷	20
期	9
DOI	https://doi.org/10.1021/acs.orglett.8b00963
出版状态	已出版 - 4 5月 2018

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abstract = "A metal-free, visible-light photoredox-catalyzed three-component [3 + 2 + 1] heteroannulation for accessing modular fluoroalkylated pyrimidines from readily available silyl enol ether, amidine, and fluoroalkyl halide is developed. This protocol distinguishes itself by broad functional group tolerance in a regioselective manner, which provides a complement to the existing methods for the construction of pharmaceutically and biologically active organofluorine compounds.",

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AU - Chu, Xue Qiang

AU - Xie, Ting

AU - Li, Lin

AU - Ge, Danhua

AU - Shen, Zhi Liang

AU - Loh, Teck Peng

PY - 2018/5/4

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AB - A metal-free, visible-light photoredox-catalyzed three-component [3 + 2 + 1] heteroannulation for accessing modular fluoroalkylated pyrimidines from readily available silyl enol ether, amidine, and fluoroalkyl halide is developed. This protocol distinguishes itself by broad functional group tolerance in a regioselective manner, which provides a complement to the existing methods for the construction of pharmaceutically and biologically active organofluorine compounds.

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Combining Fluoroalkylation and Defluorination to Enable Formal [3 + 2 + 1] Heteroannulation by Using Visible-Light Photoredox Organocatalysis

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