TY - JOUR
T1 - Conjugated Polymer Nanoparticles with Absorption beyond 1000 nm for NIR-II Fluorescence Imaging System Guided NIR-II Photothermal Therapy
AU - Song, Xingwen
AU - Lu, Xiaomei
AU - Sun, Bo
AU - Zhang, Hua
AU - Sun, Pengfei
AU - Miao, Han
AU - Fan, Quli
AU - Huang, Wei
N1 - Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/10/9
Y1 - 2020/10/9
N2 - The second near-infrared fluorescence imaging (NIR-II FI) guided NIR-II photothermal therapy (PTT) possesses advantages for cancer treatment because of its accurate diagnosis and enhanced therapeutic effects for cancer. However, developing a conjugated polymer with both excellent NIR-II fluorescence and NIR-II PTT properties encountered many hindrances, including strong nonradiative decay, low solubility in organic solution, and significant aggregation-caused quenching (ACQ) effect. Herein, a conjugated polymer TTQ-2TC with optimized absorption in NIR-II regions, good solubility in organic solvents, and bright NIR-II FI signals is obtained through introducing the alkyl-side-chain-modified bithiophene (2TC) as the electron-rich donor unit. The water-soluble nanoparticle (TTQ-2TC NPs) prepared from the conjugated polymer TTQ-2TC is used for precise NIR-II FI guided NIR-II PTT treatment. The in vivo blood and tumor imaging and therapy results show that the TTQ-2TC NPs possess high signal-to-background ratio (SBR) and perfect antitumor efficacy by NIR-II PTT.
AB - The second near-infrared fluorescence imaging (NIR-II FI) guided NIR-II photothermal therapy (PTT) possesses advantages for cancer treatment because of its accurate diagnosis and enhanced therapeutic effects for cancer. However, developing a conjugated polymer with both excellent NIR-II fluorescence and NIR-II PTT properties encountered many hindrances, including strong nonradiative decay, low solubility in organic solution, and significant aggregation-caused quenching (ACQ) effect. Herein, a conjugated polymer TTQ-2TC with optimized absorption in NIR-II regions, good solubility in organic solvents, and bright NIR-II FI signals is obtained through introducing the alkyl-side-chain-modified bithiophene (2TC) as the electron-rich donor unit. The water-soluble nanoparticle (TTQ-2TC NPs) prepared from the conjugated polymer TTQ-2TC is used for precise NIR-II FI guided NIR-II PTT treatment. The in vivo blood and tumor imaging and therapy results show that the TTQ-2TC NPs possess high signal-to-background ratio (SBR) and perfect antitumor efficacy by NIR-II PTT.
KW - NIR-II fluorescence imaging
KW - NIR-II photothermal therapy
KW - antitumor
KW - conjugated polymer
KW - signal-to-background ratio
UR - http://www.scopus.com/inward/record.url?scp=85098112844&partnerID=8YFLogxK
U2 - 10.1021/acsapm.0c00637
DO - 10.1021/acsapm.0c00637
M3 - 文献综述
AN - SCOPUS:85098112844
SN - 2637-6105
VL - 2
SP - 4171
EP - 4179
JO - ACS Applied Polymer Materials
JF - ACS Applied Polymer Materials
IS - 10
ER -
