Constructing a multienzyme cascade redox-neutral system for the synthesis of halogenated indoles

Siyu Qi; Zhuotao Tan; Qi Na; Xiaowang Zhang; Mengjiao Xu; Wei Zhuang; Ming Li; Hanjie Ying; Pingkai Ouyang; Chenjie Zhu

doi:10.1039/d2cc00811d

Constructing a multienzyme cascade redox-neutral system for the synthesis of halogenated indoles

Siyu Qi, Zhuotao Tan, Qi Na, Xiaowang Zhang, Mengjiao Xu, Wei Zhuang, Ming Li, Hanjie Ying, Pingkai Ouyang, Chenjie Zhu

生物与制药工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

3 引用（Scopus）

摘要

Inspired by biocatalytic retrosynthesis, a multienzyme cascade system containing alcohol dehydrogenase, flavin-dependent halogenase and flavin reductase was developed for the synthesis of several halogenated indoles starting from amino alcohol. This redox-neutral system not only omitted co-substrate for nicotinamide cofactor (NADH) regeneration but also showed relatively higher conversion and chemoselectivity compared with individual biotransformation. Artificial nicotinamide cofactor (BNAH) was employed to replace NADH and flavin reductase for simplifying this system, providing a more convenient strategy for halogenated indoles.

源语言	英语
期刊	Chemical Communications
DOI	https://doi.org/10.1039/d2cc00811d
出版状态	已接受/待刊 - 2022

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abstract = "Inspired by biocatalytic retrosynthesis, a multienzyme cascade system containing alcohol dehydrogenase, flavin-dependent halogenase and flavin reductase was developed for the synthesis of several halogenated indoles starting from amino alcohol. This redox-neutral system not only omitted co-substrate for nicotinamide cofactor (NADH) regeneration but also showed relatively higher conversion and chemoselectivity compared with individual biotransformation. Artificial nicotinamide cofactor (BNAH) was employed to replace NADH and flavin reductase for simplifying this system, providing a more convenient strategy for halogenated indoles.",

author = "Siyu Qi and Zhuotao Tan and Qi Na and Xiaowang Zhang and Mengjiao Xu and Wei Zhuang and Ming Li and Hanjie Ying and Pingkai Ouyang and Chenjie Zhu",

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year = "2022",

doi = "10.1039/d2cc00811d",

language = "英语",

journal = "Chemical Communications",

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TY - JOUR

T1 - Constructing a multienzyme cascade redox-neutral system for the synthesis of halogenated indoles

AU - Qi, Siyu

AU - Tan, Zhuotao

AU - Na, Qi

AU - Zhang, Xiaowang

AU - Xu, Mengjiao

AU - Zhuang, Wei

AU - Li, Ming

AU - Ying, Hanjie

AU - Ouyang, Pingkai

AU - Zhu, Chenjie

PY - 2022

Y1 - 2022

N2 - Inspired by biocatalytic retrosynthesis, a multienzyme cascade system containing alcohol dehydrogenase, flavin-dependent halogenase and flavin reductase was developed for the synthesis of several halogenated indoles starting from amino alcohol. This redox-neutral system not only omitted co-substrate for nicotinamide cofactor (NADH) regeneration but also showed relatively higher conversion and chemoselectivity compared with individual biotransformation. Artificial nicotinamide cofactor (BNAH) was employed to replace NADH and flavin reductase for simplifying this system, providing a more convenient strategy for halogenated indoles.

AB - Inspired by biocatalytic retrosynthesis, a multienzyme cascade system containing alcohol dehydrogenase, flavin-dependent halogenase and flavin reductase was developed for the synthesis of several halogenated indoles starting from amino alcohol. This redox-neutral system not only omitted co-substrate for nicotinamide cofactor (NADH) regeneration but also showed relatively higher conversion and chemoselectivity compared with individual biotransformation. Artificial nicotinamide cofactor (BNAH) was employed to replace NADH and flavin reductase for simplifying this system, providing a more convenient strategy for halogenated indoles.

UR - http://www.scopus.com/inward/record.url?scp=85129917350&partnerID=8YFLogxK

U2 - 10.1039/d2cc00811d

DO - 10.1039/d2cc00811d

M3 - 文章

C2 - 35502651

AN - SCOPUS:85129917350

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

ER -

Constructing a multienzyme cascade redox-neutral system for the synthesis of halogenated indoles

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