Continuous flow protecting-group-free synthetic approach to thiol-terminated poly(ε-caprolactone)

Ning Zhu; Yihuan Liu; Weiyang Feng; Weijun Huang; Zilong Zhang; Xin Hu; Zheng Fang; Zhenjiang Li; Kai Guo

doi:10.1016/j.eurpolymj.2016.04.010

Continuous flow protecting-group-free synthetic approach to thiol-terminated poly(ε-caprolactone)

Ning Zhu, Yihuan Liu, Weiyang Feng, Weijun Huang, Zilong Zhang, Xin Hu, Zheng Fang, Zhenjiang Li, Kai Guo

生物与制药工程学院

Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

25 引用（Scopus）

摘要

A novel continuous flow protecting-group-free synthetic approach was developed to thiol-terminated poly(ε-caprolactone). Sn(OTf)₂ catalyzed unprotected 6-mercapto-1-hexanol initiating chemoselective ring-opening polymerization of ε-caprolactone was conducted in PTFE tubular reactor. This continuous flow polymerization platform achieved quantitative chemoselectivity and fast polymerization that cannot be done in batch. By changing the [monomer]/[initiator] feed ratio, the molecular weights of products were well controlled with narrow molecular weight distributions. The structure of the resultant thiol-terminated poly(ε-caprolactone) was demonstrated by NMR, MALDI TOF MS and SEC.

源语言	英语
页（从-至）	234-239
页数	6
期刊	European Polymer Journal
卷	80
DOI	https://doi.org/10.1016/j.eurpolymj.2016.04.010
出版状态	已出版 - 1 7月 2016

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10.1016/j.eurpolymj.2016.04.010

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title = "Continuous flow protecting-group-free synthetic approach to thiol-terminated poly(ε-caprolactone)",

abstract = "A novel continuous flow protecting-group-free synthetic approach was developed to thiol-terminated poly(ε-caprolactone). Sn(OTf)2 catalyzed unprotected 6-mercapto-1-hexanol initiating chemoselective ring-opening polymerization of ε-caprolactone was conducted in PTFE tubular reactor. This continuous flow polymerization platform achieved quantitative chemoselectivity and fast polymerization that cannot be done in batch. By changing the [monomer]/[initiator] feed ratio, the molecular weights of products were well controlled with narrow molecular weight distributions. The structure of the resultant thiol-terminated poly(ε-caprolactone) was demonstrated by NMR, MALDI TOF MS and SEC.",

keywords = "Chemoselective ring-opening polymerization, Sn(OTf), Thiol-terminated poly(ε-caprolactone)",

author = "Ning Zhu and Yihuan Liu and Weiyang Feng and Weijun Huang and Zilong Zhang and Xin Hu and Zheng Fang and Zhenjiang Li and Kai Guo",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

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doi = "10.1016/j.eurpolymj.2016.04.010",

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T1 - Continuous flow protecting-group-free synthetic approach to thiol-terminated poly(ε-caprolactone)

AU - Zhu, Ning

AU - Liu, Yihuan

AU - Feng, Weiyang

AU - Huang, Weijun

AU - Zhang, Zilong

AU - Hu, Xin

AU - Fang, Zheng

AU - Li, Zhenjiang

AU - Guo, Kai

PY - 2016/7/1

Y1 - 2016/7/1

N2 - A novel continuous flow protecting-group-free synthetic approach was developed to thiol-terminated poly(ε-caprolactone). Sn(OTf)2 catalyzed unprotected 6-mercapto-1-hexanol initiating chemoselective ring-opening polymerization of ε-caprolactone was conducted in PTFE tubular reactor. This continuous flow polymerization platform achieved quantitative chemoselectivity and fast polymerization that cannot be done in batch. By changing the [monomer]/[initiator] feed ratio, the molecular weights of products were well controlled with narrow molecular weight distributions. The structure of the resultant thiol-terminated poly(ε-caprolactone) was demonstrated by NMR, MALDI TOF MS and SEC.

AB - A novel continuous flow protecting-group-free synthetic approach was developed to thiol-terminated poly(ε-caprolactone). Sn(OTf)2 catalyzed unprotected 6-mercapto-1-hexanol initiating chemoselective ring-opening polymerization of ε-caprolactone was conducted in PTFE tubular reactor. This continuous flow polymerization platform achieved quantitative chemoselectivity and fast polymerization that cannot be done in batch. By changing the [monomer]/[initiator] feed ratio, the molecular weights of products were well controlled with narrow molecular weight distributions. The structure of the resultant thiol-terminated poly(ε-caprolactone) was demonstrated by NMR, MALDI TOF MS and SEC.

KW - Chemoselective ring-opening polymerization

KW - Sn(OTf)

KW - Thiol-terminated poly(ε-caprolactone)

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U2 - 10.1016/j.eurpolymj.2016.04.010

DO - 10.1016/j.eurpolymj.2016.04.010

M3 - 文章

AN - SCOPUS:84964319311

SN - 0014-3057

VL - 80

SP - 234

EP - 239

JO - European Polymer Journal

JF - European Polymer Journal

ER -

Continuous flow protecting-group-free synthetic approach to thiol-terminated poly(ε-caprolactone)

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