Continuous synthesis and anti-myocardial injury of tanshinone IIA derivatives

Yin Lin Qin, Lei Chen, Wei He, Mei Su, Qiu Jin, Zheng Fang, Ping Kai Ouyang, Kai Guo

科研成果: 期刊稿件文章同行评审

9 引用 (Scopus)

摘要

A series of tanshinone IIA derivatives were synthesized through sulfonation, slat-forming, chlorination, and amidation reactions. Meanwhile, anti-myocardial injury activity was evaluated in vitro. D8 and D9 exhibited a slightly higher anti-myocardial injury (5.78, 7.46 μM) activity compared with esmolol (8.12 μM). In addition, they also displayed a concentration-dependent inhibition on the anti-myocardial injury.

源语言英语
页(从-至)139-147
页数9
期刊Journal of Asian Natural Products Research
20
2
DOI
出版状态已出版 - 1 2月 2018

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