Controlled Synthesis of 1,3,5-Oxadiazin-2-ones and Oxazolones through Regioselective Iodocyclization of Ynamides

Hai Huang, Xiaolin Zhu, Guangke He, Qi Liu, Junzhen Fan, Hongjun Zhu

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46 引用 (Scopus)

摘要

Two efficient processes based on the iodocyclization of ynamides have been developed: (i) N-alkynyl tert-butyloxycarbamates were found to undergo a rare 6-exo-dig ring closure reaction affording 1,3,5-oxadiazin-2-ones by using acetonitrile as solvent; (ii) In the absence of acetonitrile, N-alkynyl tert-butyloxycarbamates could undergo 5-endo-dig cyclization providing oxazolones. (Chemical Equation Presented).

源语言英语
页(从-至)2510-2513
页数4
期刊Organic Letters
17
10
DOI
出版状态已出版 - 15 5月 2015

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