Copper-catalyzed [4+2] oxidative annulation of α,β-unsaturated ketoxime acetates with ethyl trifluoropyruvate

Huan Yan, Gaochen Xu, Meng Gu, Sai Zhang, Qinghuan Wu, Jingjing Meng, Ning Zhu, Zheng Fang, Jindian Duan, Kai Guo

科研成果: 期刊稿件文章同行评审

11 引用 (Scopus)

摘要

A novel route for tandem C-N/C-O formation via copper-catalyzed [4+2] oxidative annulation of α,β-unsaturated ketoxime acetates with ethyl trifluoropyruvate to synthesize valuable trifluoromethyl-containing 2H-1,3-oxazines in moderate to good yields is developed. This procedure represents the first [4+2] oxidative annulation of oxime derivatives with activated C = O bonds and provides an alternative route towards functionalized 2H-1,3-oxazines.

源语言英语
页(从-至)6757-6760
页数4
期刊Chemical Communications
58
47
DOI
出版状态已出版 - 18 5月 2022

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