Copper-Catalyzed Oxidative Dehydrogenative C(sp3)−H Bond Amination of (Cyclo)Alkanes using NH-Heterocycles as Amine Sources

Chang Sheng Wang, Xiao Feng Wu, Pierre H. Dixneuf, Jean François Soulé

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26 引用 (Scopus)

摘要

A copper-catalyzed oxidative C(sp3)−H/N−H coupling of NH-heterocycles with affordable (cyclo)alkanes has been developed. This procedure involves C(sp3)−N bond formation through a radical pathway generated by homolytic cleavage of di-tert-butyl peroxide and trapping of the radical(s) by copper catalysts. The reaction tolerates a series of functional groups, such as bromo, fluoro, ester, ketone, nitrile, methyl, and methoxy. free-NH-containing indoles, pyrroles, pyrazoles, indazoles, and benzotriazoles are successfully N-alkylated.

源语言英语
页(从-至)3075-3082
页数8
期刊ChemSusChem
10
15
DOI
出版状态已出版 - 10 8月 2017
已对外发布

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