摘要
A copper-catalyzed oxidative C(sp3)−H/N−H coupling of NH-heterocycles with affordable (cyclo)alkanes has been developed. This procedure involves C(sp3)−N bond formation through a radical pathway generated by homolytic cleavage of di-tert-butyl peroxide and trapping of the radical(s) by copper catalysts. The reaction tolerates a series of functional groups, such as bromo, fluoro, ester, ketone, nitrile, methyl, and methoxy. free-NH-containing indoles, pyrroles, pyrazoles, indazoles, and benzotriazoles are successfully N-alkylated.
源语言 | 英语 |
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页(从-至) | 3075-3082 |
页数 | 8 |
期刊 | ChemSusChem |
卷 | 10 |
期 | 15 |
DOI | |
出版状态 | 已出版 - 10 8月 2017 |
已对外发布 | 是 |