Copper-TEMPO-catalyzed synthesis of α-ketoamides: Via tandem sp3C-H aerobic oxidation and amination of phenethyl alcohol derivatives

Chengkou Liu, Zhao Yang, Shiyu Guo, Yu Zeng, Ning Zhu, Xin Li, Zheng Fang, Kai Guo

科研成果: 期刊稿件文章同行评审

17 引用 (Scopus)

摘要

An efficient copper-TEMPO-catalyzed one-pot synthesis of α-ketoamides from phenethyl alcohol derivatives was developed firstly. Moreover, molecular oxygen in open air was employed as the oxidant with a broad substrate scope, which makes this methodology more practical. Based on some control experiments, a plausible mechanism was proposed.

源语言英语
页(从-至)8570-8575
页数6
期刊Organic and Biomolecular Chemistry
14
36
DOI
出版状态已出版 - 2016

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