Copper(I)-Catalyzed [4+2] Oxidative Annulation of α,β-Unsaturated Ketoxime Acetates with Cyclopropanols toward Functional Pyridines

Qinghuan Wu, Gaochen Xu, Yuguang Li, Lei Shen, Zheng Fang, Jindian Duan, Kai Guo

科研成果: 期刊稿件文章同行评审

2 引用 (Scopus)

摘要

A Cu(I)-catalyzed [4+2] oxidative annulation of α,β-unsaturated ketoxime acetates with cyclopropanols has been developed for the synthesis of 2,4,5-trisubstituted pyridines in 28–76% yields. This method employs cyclopropanols as C2 synthons and features various functional group compatibility and gram-scale synthesis. In addition, a plausible reaction pathway was proposed based on the mechanism studies.

源语言英语
页(从-至)4310-4316
页数7
期刊Advanced Synthesis and Catalysis
365
23
DOI
出版状态已出版 - 5 12月 2023

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