Copper(II)-Mediated Ring Opening/Alkynylation of Tertiary Cyclopropanols by Using Nonmodified Terminal Alkynes

Bu Qing Cheng, Si Xuan Zhang, Yan Ying Cui, Xue Qiang Chu, Weidong Rao, Haiyan Xu, Guo Zhi Han, Zhi Liang Shen

科研成果: 期刊稿件文章同行评审

28 引用 (Scopus)

摘要

The copper(II)-mediated ring opening/alkynylation of cyclopropanol by employing inexpensive and commercially available terminal alkyne is developed. The reactions proceeded efficiently to afford synthetically useful alk-4-yn-1-ones in moderate to good yields with good functional group tolerance. Control experiments showed that the reaction presumably proceeds via the formation of intermediates of copper homoenolate and/or alkynylcopper species.

源语言英语
页(从-至)5456-5461
页数6
期刊Organic Letters
22
14
DOI
出版状态已出版 - 17 7月 2020

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