Decarboxylative Coupling of Ketoacids with Allylic Acetates

Xiaoyu Zhang, Fanyi Hou, Yinlei Zhang, Bowen Li, Peizhong Xie, Teck Peng Loh

科研成果: 期刊稿件文章同行评审

摘要

We developed a novel, metal-free catalytic system for synthesizing a broad range of itaconates using α-ketoacids and allylic acetate. This method, leveraging phosphine and Mes-Acr+(BF4-) catalysts, has proven versatile, enabling the efficient itaconation of peptides, the synthesis of bioactive itaconates, and the preparation of an itaconate-based bio-orthogonal probe.

源语言英语
期刊Organic Letters
DOI
出版状态已接受/待刊 - 2024

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