@inproceedings{9b62bdf48bc046db8ed2f132a927406f,
title = "Design, syntheses and biological evaluation of 3-arylurea-5-fluoroindolin-2-one derivatives",
abstract = "Sixteen 3-arylurea-5-fluoroindolin-2-one derivatives were designed according to the principle of fragment based drug discovery and synthesized with 5-fluoroisatin as the starting material. The obtained structures were identified by 1H NMR, MS and elemental analysis. In vitro evaluation of antitumor bioactivity was performed by MTT method. Most of synthesized compounds showed antitumor activities, especially, activities of 6a, 6h, and 6j in tumor inhibition were better than others.",
keywords = "3-arylurea-5-fluoroindolin-2-one, Activity, Antitumor, Synthesis",
author = "Zhao Yang and Zhixiang Wang and Zheng Fang and Kai Guo",
year = "2013",
doi = "10.4028/www.scientific.net/AMR.634-638.922",
language = "英语",
isbn = "9783037855898",
series = "Advanced Materials Research",
number = "1",
pages = "922--925",
booktitle = "Advances in Chemical, Material and Metallurgical Engineering",
edition = "1",
note = "2012 2nd International Conference on Chemical, Material and Metallurgical Engineering, ICCMME 2012 ; Conference date: 15-12-2012 Through 16-12-2012",
}