Diastereocontrol via lewis acid-promoted ene reaction with glyoxylates and its application to stereocontrolled synthesis of a 22R-hydroxy-23-carboxylate steroid side chain

Koichi Mikami; Teck Peng Loh; Takeshi Nakai

doi:10.1016/S0040-4039(00)82332-1

Diastereocontrol via lewis acid-promoted ene reaction with glyoxylates and its application to stereocontrolled synthesis of a 22R-hydroxy-23-carboxylate steroid side chain

Koichi Mikami, Teck Peng Loh, Takeshi Nakai

Institute of Science Tokyo

科研成果: 期刊稿件 › 文章 › 同行评审

49 引用（Scopus）

摘要

Taking the judicious choice of the Lewis acid employed, the glyoxylate ene reactions are shown to proceed with a high level of either erythro or threo diastereoselection. The utility of the ene methodology is demonstrated through the stereocontrolled synthesis of a 22R-hydroxy-23-carboxylate steroid side chain.

源语言	英语
页（从-至）	6305-6308
页数	4
期刊	Tetrahedron Letters
卷	29
期	48
DOI	https://doi.org/10.1016/S0040-4039(00)82332-1
出版状态	已出版 - 1988
已对外发布	是

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abstract = "Taking the judicious choice of the Lewis acid employed, the glyoxylate ene reactions are shown to proceed with a high level of either erythro or threo diastereoselection. The utility of the ene methodology is demonstrated through the stereocontrolled synthesis of a 22R-hydroxy-23-carboxylate steroid side chain.",

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AU - Loh, Teck Peng

AU - Nakai, Takeshi

PY - 1988

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AB - Taking the judicious choice of the Lewis acid employed, the glyoxylate ene reactions are shown to proceed with a high level of either erythro or threo diastereoselection. The utility of the ene methodology is demonstrated through the stereocontrolled synthesis of a 22R-hydroxy-23-carboxylate steroid side chain.

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Diastereocontrol via lewis acid-promoted ene reaction with glyoxylates and its application to stereocontrolled synthesis of a 22R-hydroxy-23-carboxylate steroid side chain

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