Electrochemical Oxidative ortho-Selective Trifluoromethylation of N-Arylamides

Jinze Du, Di Gao, Dong Zhang, Xinxin Lin, Chengkou Liu, Ning Zhu, Zhao Yang, Wei He, Zheng Fang, Kai Guo

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4 引用 (Scopus)

摘要

A metal-catalyst-free and external-oxidant-free electrochemical oxidative radical C−H ortho-trifluoromethylation is presented. The reaction specifically occurred at the ortho-position of anilides without directing groups. Various anilides showed good tolerance to provide the desired products in moderate to good yields. In addition, the gram-scale amplified product of benzanilide was obtained with a yield of 64 %, which proved that it has a certain application potential.

源语言英语
文章编号e202101411
期刊ChemElectroChem
9
5
DOI
出版状态已出版 - 11 3月 2022

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