Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies

Qinglin Xu, Weijun Xiu, Qiang Li, Yu Zhang, Xiaoye Li, Meng Ding, Dongliang Yang, Yongbin Mou, Heng Dong

科研成果: 期刊稿件文献综述同行评审

52 引用 (Scopus)

摘要

With the widespread prevalence of drug-resistant pathogens, traditional antibiotics have limited effectiveness and do not yield the desired outcomes. Recently, alternative antibacterial therapies based on ultrasound (US) have been explored to overcome the crisis of bacterial pathogens. Antimicrobial sonodynamic therapy (aSDT) offers an excellent solution that relies on US irradiation to produce reactive oxygen species (ROS) and achieve antibiotic-free mediated antimicrobial effects. In addition, aSDT possesses the advantage of superior tissue penetrability of US compared to light irradiation, demonstrating great feasibility in treating deep infections. Although existing conventional sonosensitizers can produce ROS for antimicrobial activity, some limitations, such as low penetration rate, nonspecific distribution and poor ROS production under hypoxic conditions, result in suboptimal sterilization in aSDT. Recently, emerging nanosonosensitizers have enormous advantages as high-performance agents in aSDT, which overcome the deficiencies of conventional sonosensitizers as described above. Thus, nanosonosensitizer-mediated aSDT has a bright future for the management of bacterial infections. This review classifies the current available nanosonosensitizers and provides an overview of the mechanisms, biomedical applications, recent advances and perspectives of aSDT.

源语言英语
文章编号100559
期刊Materials Today Bio
19
DOI
出版状态已出版 - 4月 2023

指纹

探究 'Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies' 的科研主题。它们共同构成独一无二的指纹。

引用此