Enantioselective syntheses of the alkaloids cis -195A (pumiliotoxin C) and trans -195A based on multiple applications of asymmetric catalysis

Martin Gärtner; Jianping Qu; Günter Helmchen

doi:10.1021/jo202241b

Enantioselective syntheses of the alkaloids cis -195A (pumiliotoxin C) and trans -195A based on multiple applications of asymmetric catalysis

Martin Gärtner, Jianping Qu, Günter Helmchen

Heidelberg University

科研成果: 期刊稿件 › 文章 › 同行评审

31 引用（Scopus）

摘要

Short enantio- and diastereoselective syntheses of the decahydroquinoline alkaloids cis- (pumiliotoxin C) and trans-195A are presented. Key steps are an enantioselective iridium-catalyzed allylic amination, a Suzuki-Miyaura coupling, a catalyst-controlled copper-catalyzed 1,4-addition, and a reductive amination.

源语言	英语
页（从-至）	1186-1190
页数	5
期刊	Journal of Organic Chemistry
卷	77
期	2
DOI	https://doi.org/10.1021/jo202241b
出版状态	已出版 - 20 1月 2012
已对外发布	是

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AB - Short enantio- and diastereoselective syntheses of the decahydroquinoline alkaloids cis- (pumiliotoxin C) and trans-195A are presented. Key steps are an enantioselective iridium-catalyzed allylic amination, a Suzuki-Miyaura coupling, a catalyst-controlled copper-catalyzed 1,4-addition, and a reductive amination.

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Enantioselective syntheses of the alkaloids cis -195A (pumiliotoxin C) and trans -195A based on multiple applications of asymmetric catalysis

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